ArticleAmerican journal of Alzheimer's disease and other dementias2018
Women's Pregnancy Life History and Alzheimer's Risk: Can Immunoregulation Explain the Link?
Article in American journal of Alzheimer's disease and other dementias, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- The lipidomic architecture of the mouse brain.Nature · 2026Article
- Women's midlife: the front line of Alzheimer prevention.The Journal of clinical investigation · 2026Review
- Pregnancy and breastfeeding are associated with less later-life cognitive decline in a longitudinal, prospective cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Biological Sex Disparities in Alzheimer's Disease.Current topics in behavioral neurosciences · 2025Review
- Research Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status.Demography · 2024Article
- Higher Number of Children Is Associated With Increased Risk of Generalization Deficits in Older African American Women.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The association between testosterone and serum soluble klotho in the females: evidence from the NHANES database.Frontiers in endocrinology · 2024Article
- Effects of reproductive experience on cost-benefit decision making in female rats.Frontiers in behavioral neuroscience · 2024Article
- Walking for Cognitive Health: Previous Parity Moderates the Relationship Between Self-Reported Walking and Cognition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Review
- The mediating role of socioeconomic status on the relationship between pregnancy history and later-life cognition.Climacteric : the journal of the International Menopause Society · 2022Article
- The Effect of Cumulative Lifetime Estrogen Exposure on Cognition in Depressed Versus Non-Depressed Older Women.Journal of geriatric psychiatry and neurology · 2022Article
- Associations between reproductive history, hormone use,Frontiers in aging neuroscience · 2022Article
- Endogenous and Exogenous Estrogen Exposures: How Women's Reproductive Health Can Drive Brain Aging and Inform Alzheimer's Prevention.Frontiers in aging neuroscience · 2022Review
- Associations of Parity With Change in Global Cognition and Incident Cognitive Impairment in Older Women.Frontiers in aging neuroscience · 2022Article
- Sex Hormones, Sleep, and Memory: Interrelationships Across the Adult Female Lifespan.Frontiers in aging neuroscience · 2022Review
- Cardiovascular profiles associated with white matter hyperintensities in healthy young women.Frontiers in physiology · 2022Article
- Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- A history of previous childbirths is linked to women's white matter brain age in midlife and older age.Human brain mapping · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPregnancy is associated with improvement in immunoregulation that persists into the geriatric phase. Impaired immunoregulation is implicated in Alzheimer's disease (AD) pathogenesis. Hence, we investigate the relationship between pregnancy and AD.
methodsCross-sectional cohort of British women (N = 95). Cox proportional hazards modeling assessed the putative effects of cumulative months pregnant on AD risk and the mutually adjusted effects of counts of first and third trimesters on AD risk.
resultsCumulative number of months pregnant, was associated with lower AD risk (β = -1.90, exp(β) = 0.15, P = .02). Cumulative number of first trimesters was associated with lower AD risk after adjusting for third trimesters (β = -3.83, exp(β) = 0.02, P < .01), while the latter predictor had no significant effect after adjusting for the former.
conclusionsOur observation that first trimesters (but not third trimesters) conferred protection against AD is more consistent with immunologic effects, which are driven by early gestation, than estrogenic exposures, which are greatest in late gestation. Results may justify future studies with immune biomarkers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.