ArticleMolecules (Basel, Switzerland)2018
Environmentally Friendly Approach to Knoevenagel Condensation of Rhodanine in Choline Chloride: Urea Deep Eutectic Solvent and QSAR Studies on Their Antioxidant Activity.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 28 citations in OpenAlex.
- How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?Pharmaceuticals (Basel, Switzerland) · 2024Review
- Synthesis of 5-arylidenerhodanines in L-proline-based deep eutectic solvent.Beilstein journal of organic chemistry · 2023Article
- Lipoxygenase Inhibition Activity of Coumarin Derivatives-QSAR and Molecular Docking Study.Pharmaceuticals (Basel, Switzerland) · 2020Article
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7 authors at 1 institution in 1 country.
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Abstract
A series of rhodanine derivatives was synthesized in the Knoevenagel condensation of rhodanine and different aldehydes using choline chloride:urea (1:2) deep eutectic solvent. This environmentally friendly and catalyst free approach was very effective in the condensation of rhodanine with commercially available aldehydes, as well as the ones synthesized in our laboratory. All rhodanine derivatives were subjected to 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity investigation and quantitative structure-activity relationship (QSAR) studies were performed to elucidate their structure-activity relationship. The best multiple linear QSAR model demonstrate a stability in the internal validation and Y-randomization (
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