Evidence map›Paper›PMID 30060584›Full record

ArticleMolecules (Basel, Switzerland)2018

Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives.

Maria Luisa Di Gioia, Monica Nardi, Paola Costanzo, Antonio De Nino, Loredana Maiuolo, Manuela Oliverio, Antonio Procopio

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.Green chemistry : an international journal and green chemistry resource : GC · 2025
    Review
  3. C2 to C6 biobased carbonyl platforms for fine chemistry.Beilstein journal of organic chemistry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Maria Luisa Di GioiaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy. ml.digioia@unical.it.ORCID 0000-0001-5469-5459
Monica NardiDepartment of Chemistry and Chemical Technologies of the University of Calabria, Cubo 12C, Arcavacata di Rende, 87036 Cosenza, Italy. monica.nardi@unical.it.ORCID 0000-0001-6617-9320
Paola CostanzoDepartment of Health Sciences, Magna Graecia University, Viale Europa, 88100 Germaneto CZ, Italy. pcostanzo@unicz.it.ORCID 0000-0002-2205-1541
Antonio De NinoDepartment of Chemistry and Chemical Technologies of the University of Calabria, Cubo 12C, Arcavacata di Rende, 87036 Cosenza, Italy. antonio.denino@unical.it.ORCID 0000-0002-9513-5199
Loredana MaiuoloDepartment of Chemistry and Chemical Technologies of the University of Calabria, Cubo 12C, Arcavacata di Rende, 87036 Cosenza, Italy. loredana.maiuolo@unical.it.
Manuela OliverioDepartment of Health Sciences, Magna Graecia University, Viale Europa, 88100 Germaneto CZ, Italy. m.oliverio@unicz.it.ORCID 0000-0002-1918-5813
Antonio ProcopioDepartment of Health Sciences, Magna Graecia University, Viale Europa, 88100 Germaneto CZ, Italy. procopio@unicz.it.
Magna Graecia University · ITUniversity of Calabria · ITSan Raffaele University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of novel synthetic routes to produce bioactive compounds starting from renewable sources has become an important research area in organic and medicinal chemistry. Here, we present a low-cost procedure for the tunable and selective conversion of biomass-produced furfural to cyclopentenone derivatives using a mixture of choline chloride and urea as a biorenewable deep eutectic solvent (DES). The proposed medium is a nontoxic, biodegradable, and could be reused up to four times without any unfavorable effect on the reaction yield. The process is tunable, clean, cheap, simple and scalable and meets most of the criteria; therefore, it can be considered as an environmental sustainable process in a natural reaction medium.

Indexed as

Biodegradation, EnvironmentalBiomassChemistry, PharmaceuticalCholineCyclopentanesFuraldehydeGreen Chemistry TechnologyHumansSolventsTemperatureUreaCholineCyclopentanescyclopentenoneFuraldehydeSolventsUreabiomass conversioncyclopentenonesdeep eutectic solventsfurfuralgreen chemistry

Identifiers

PMID30060584
PMCPMC6222497
OpenAlexW2883662753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.