ArticleInternational journal of molecular sciences2018
Effects of Lipid Saturation on the Surface Properties of Human Meibum Films.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Oxidation-Dependent Behavior of Saturated and Unsaturated Phosphatidylcholine Model Membranes: Insights from Langmuir Monolayers and TBARS Analysis.The Journal of membrane biology · 2026Review
- Direct Correlation of Levels of Meibum Cholesteryl Esters, Hydrocarbon Chain Saturation, and Protein With Lipid Structure, in Relation to Age and Dry Eye.Investigative ophthalmology & visual science · 2026Article
- Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy.Investigative ophthalmology & visual science · 2026Article
- Decipher 'Em All: A Profiling Study on the Effects of Acyl Groups inLangmuir : the ACS journal of surfaces and colloids · 2024Article
- Corneal wound healing in spaceflight: implications of microgravity-induced molecular signaling modulations for corneal health.Eye (London, England) · 2024Article
- Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis.Investigative ophthalmology & visual science · 2023Article
- Surface Chemistry Study of the Interactions of Sesame Oil with Meibomian Films.Molecules (Basel, Switzerland) · 2022Article
- A spectroscopic study of the composition and conformation of cholesteryl and wax esters purified from meibum.Chemistry and physics of lipids · 2021Article
- Meibum Lipid Composition and Conformation in Parkinsonism.EC ophthalmology · 2021Article
- Interactions of Meibum and Tears with Mucomimetic Polymers: A Hint towards the Interplay between the Layers of the Tear Film.International journal of molecular sciences · 2021Article
- Evidence for Phospholipids on the Surface of Human Tears.Investigative ophthalmology & visual science · 2020Article
- Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production.International journal of molecular sciences · 2020Article
- Meibum lipid hydrocarbon chain branching and rheology after hematopoietic stem cell transplantation.Biochemistry and biophysics reports · 2020Article
- Structural Differences in Meibum From Teenagers Without and With Dry Eye and Allogeneic Hematologic Stem Cell Transplantations.Journal of pediatric hematology/oncology · 2020Article
- Concentration dependent cholesteryl-ester and wax-ester structural relationships and meibomian gland dysfunction.Biochemistry and biophysics reports · 2020Article
- Article
- Structural Differences in Meibum From Donors After Hematopoietic Stem Cell Transplantations.Cornea · 2019Article
- Lipid Saturation and the Rheology of Human Tear Lipids.International journal of molecular sciences · 2019Article
- Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction.Investigative ophthalmology & visual science · 2019Article
- Human meibum chain branching variability with age, gender and meibomian gland dysfunction.The ocular surface · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Elevated levels of acyl chain saturation of meibomian lipids are associated with vastly different effects: from enhanced tear film (TF) stability in infants to shortened TF breakup time in meibomian gland disease patients. Thus it is important to study the effect of saturation on the surface properties of human meibum (MGS). Therefore, MGS films (1, 2, 3, 4, 5, 10, 25, 50, 67, and 100% saturation) were spread at the air/water interface of a Langmuir surface balance. The layers' capability to reorganize during dynamic area changes was accessed via the surface pressure (π)-area (A) compression isotherms and step/relaxation dilatational rheology studies. Film structure was monitored with Brewster angle microscopy. The raise in the % (at ≥10%) of saturation resulted in the formation of stiffer, thicker, and more elastic films at π ≥ 12 mN/m with the effects being proportional to the saturation level. At the same time, at low (≤10 mN/m) π the raise in saturation resulted in altered spreading and heterogeneous structure of MGS layers. The strong impact of saturation on MGS surface properties correlates with our recent spectroscopy study, which demonstrated that saturation induced increase of MGS acyl chain order, phase transition temperature, and cooperativity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.