Evidence map›Paper›PMID 30060561›Full record

ArticleInternational journal of molecular sciences2018

Chemokine CCL25 Induces Migration and Extracellular Matrix Production of Anulus Fibrosus-Derived Cells.

Stefan Stich, Anke Möller, Mario Cabraja, Jan Philipp Krüger, Sylvia Hondke, Michaela Endres, Jochen Ringe, Michael Sittinger

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Advances and Prospects in Biomaterials for Intervertebral Disk Regeneration.Frontiers in bioengineering and biotechnology · 2021
    Review
  10. Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus.International journal of molecular sciences · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Stefan StichTissue Engineering Laboratory, Berlin-Brandenburg Center for Regenerative Therapies, and Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universitätzu Berlin and Berlin Institute of Health, 10117 Berlin, Germany. stefan.stich@charite.de.ORCID 0000-0001-8576-0786
Anke MöllerTissue Engineering Laboratory, Berlin-Brandenburg Center for Regenerative Therapies, and Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universitätzu Berlin and Berlin Institute of Health, 10117 Berlin, Germany. anke-moeller-fn@web.de.ORCID 0000-0002-0424-549X
Mario CabrajaDepartment of Spinal Surgery, VivantesAuguste-Viktoria-Hospital, 12157 Berlin, Germany. mario.cabraja@vivantes.de.
Jan Philipp KrügerTransTissue Technologies GmbH, 10117 Berlin, Germany. jan-philipp.krueger@transtissue.com.
Sylvia HondkeTransTissue Technologies GmbH, 10117 Berlin, Germany. sylvia.hondke@transtissue.com.ORCID 0000-0001-7742-5128
Michaela EndresTransTissue Technologies GmbH, 10117 Berlin, Germany. michaela.endres@transtissue.com.
Jochen RingeTissue Engineering Laboratory, Berlin-Brandenburg Center for Regenerative Therapies, and Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universitätzu Berlin and Berlin Institute of Health, 10117 Berlin, Germany. jochen.ringe@charite.de.
Michael SittingerTissue Engineering Laboratory, Berlin-Brandenburg Center for Regenerative Therapies, and Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universitätzu Berlin and Berlin Institute of Health, 10117 Berlin, Germany. michael.sittinger@charite.de.
Humboldt-Universität zu Berlin · DETransTissue (Germany) · DEAuguste-Viktoria-Klinik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration is a major source of back pain. For intervertebral disc regeneration after herniation a fast closure of anulus fibrosus (AF) defects is crucial. Here, the use of the C-C motif chemokine ligand 25 (CCL)25 in comparison to differentiation factors such as transforming growth factor (TGF)β3, bone morphogenetic protein (BMP)2, BMP7, BMP12, and BMP14 (all in concentrations of 10, 50 and 100 ng/mL) was tested in an in vitro micro mass pellet model with isolated and cultivated human AF-cells (

Indexed as

Cell MovementChemotaxisAnnulus FibrosusBone Morphogenetic ProteinsCells, CulturedChemokines, CCCollagen Type IExtracellular MatrixHumansProteoglycansTransforming Growth Factor beta3Bone Morphogenetic ProteinsCCL25 protein, humanChemokines, CCCollagen Type IProteoglycansTransforming Growth Factor beta3anulus fibrosusCCL25chemotaxisdifferentiationextracellular matrixTECKtissue regeneration

Identifiers

PMID30060561
PMCPMC6121557
OpenAlexW2882980134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.