ArticleProceedings of the National Academy of Sciences of the United States of America1986
Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Single-cell RNA sequencing of mid-to-late stage spider embryos: new insights into spider development.BMC genomics · 2024Article
- Structure of theInternational journal of molecular sciences · 2023Article
- Rapid Homeostatic Turnover of Embryonic ECM during Tissue Morphogenesis.Developmental cell · 2020Article
- Gene Knock-Ins inGenetics · 2020Article
- Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo.Human molecular genetics · 2017Article
- Cyclic nucleotide signaling is required during synaptic refinement at the Drosophila neuromuscular junction.Developmental neurobiology · 2017Article
- Article
- mef2 activity levels differentially affect gene expression during Drosophila muscle development.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
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- Nebulin regulates the assembly and lengths of the thin filaments in striated muscle.The Journal of cell biology · 2005Article
- Biphasic modulation of synaptic transmission by hypertonicity at the embryonic Drosophila neuromuscular junction.The Journal of physiology · 2002Article
- Alteration in the cytosolic triacylglycerol biosynthetic machinery leads to decreased cell growth and triacylglycerol synthesis in oleaginous yeast.The Biochemical journal · 2002Article
- small bristles is required for the morphogenesis of multiple tissues during Drosophila development.Genetics · 2001Article
- Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight.Plant physiology · 2001Article
- Two independent pathways mediated by cAMP and protein kinase A enhance spontaneous transmitter release at Drosophila neuromuscular junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Specific myosin heavy chain mutations suppress troponin I defects in Drosophila muscles.The Journal of cell biology · 1999Article
- Transposable element insertions respecify alternative exon splicing in three Drosophila myosin heavy chain mutants.Genetics · 1998Article
- Splice-junction elements and intronic sequences regulate alternative splicing of the Drosophila myosin heavy chain gene transcript.Genetics · 1997Article
- Myosin heavy chain isoforms regulate muscle function but not myofibril assembly.The EMBO journal · 1996Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Mutations of the myosin heavy-chain (MHC) gene of Drosophila melanogaster were identified among a group of dominant flightless and recessive lethal mutants (map position 2-52, 36A8-B1,2). One mutation is a 0.1-kilobase deletion in the 5' region of the MHC gene and reduces MHC protein in the leg and thoracic muscles of heterozygotes to levels found in 36AC haploids. Three mutations are insertions of 8-to 10-kilobase DNA elements within the MHC gene and produce truncated MHC transcripts. Heterozygotes of these insertional mutations possess levels of MHC intermediate between those of haploids and diploids. An additional mutation has no gross alteration of the MHC gene or its RNA transcripts. Although leg and larval muscles function normally in each mutant heterozygote, indirect flight muscles are defective and possess disorganized myofibrils. Homozygous mutants die during embryonic or larval development and display abnormal muscle function prior to death. These findings provide direct genetic evidence that the MHC gene at 36B (2L) is essential for both larval and adult muscle development and function. The results are consistent with the previous molecular evidence that Drosophila, unlike other organisms, has only a single muscle MHC gene per haploid genome. Quantitative expression of both copies of the MHC gene is required for function of indirect flight muscle, whereas expression of a single MHC gene is sufficient for function of larval muscles and adult tubular muscles.
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