ReviewNutrients2018
Zinc and Sepsis.
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.PLoS genetics · 2025Pooled it
- Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker.Redox biology · 2021Trial
- Prevalence of Zinc Deficiency in Japanese Patients on Peritoneal Dialysis: Comparative Study in Patients on Hemodialysis.Nutrients · 2020Trial
- Observational
- Zinc regulates the balance of specific gut microbiota through MTF1/Nrf2 and mitigates ferroptosis through activation of PINK1/Parkin/mitophagy via the gut-kidney axis in sepsis-associated acute kidney injury in pregnant mice.Apoptosis : an international journal on programmed cell death · 2026Article
- Low zinc status and long-term risk of incident sepsis in patients with type 2 diabetes: a multicenter cohort study.Frontiers in nutrition · 2026Article
- Master transcriptional regulator SaeS inVirulence · 2025Article
- The Interplay Between Nutrition and Microbiota and the Role of Probiotics and Symbiotics in Pediatric Infectious Diseases.Nutrients · 2025Review
- Tracing Zinc's Role in Preterm Infants' Health: A Narrative Review.Advances in nutrition (Bethesda, Md.) · 2024Review
- The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuatedeLife · 2024Article
- Article
- Zinc Deficiency as a General Feature of Cancer: a Review of the Literature.Biological trace element research · 2024Review
- Sepsis during short bowel syndrome hospitalizations: Identifying trends, disparities, and clinical outcomes in the United States.World journal of gastrointestinal pathophysiology · 2024Article
- Achievement of adequate nutrition contributes to maintaining the skeletal muscle area in patients with sepsis undergoing early mobilization: a retrospective observational study.BMC nutrition · 2024Article
- Nerve Regeneration with a Scaffold Incorporating an Absorbable Zinc-2% Iron Alloy Filament to Improve Axonal Guidance.Pharmaceutics · 2023Article
- The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis.Antioxidants (Basel, Switzerland) · 2023Review
- Transcriptome analysis of six tissues obtained post-mortem from sepsis patients.Journal of cellular and molecular medicine · 2023Article
- Article
- Why is manganese so valuable to bacterial pathogens?Frontiers in cellular and infection microbiology · 2023Review
- Free Zinc as a Predictive Marker for COVID-19 Mortality Risk.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis, defined as a "life-threatening organ dysfunction caused by a dysregulated host-response to infection" is a major health issue worldwide and still lacks a fully elucidated pathobiology and uniform diagnostic tests. The trace element zinc is known to be crucial to ensure an appropriate immune response. During sepsis a redistribution of zinc from serum into the liver has been observed and several studies imply a correlation between zinc and sepsis outcome. Therefore the alterations of zinc concentrations in different tissues might serve as one part of the host's defense mechanism against pathogens during sepsis by diverse mechanisms. It has been suggested that zinc is involved in nutritional immunity, acts as a hepatoprotective agent, or a differentiation signal for innate immune cells, or supports the synthesis of acute phase proteins. Further knowledge about these events could help in the evaluation of how zinc could be optimally applied to improve treatment of septic patients. Moreover, the changes in zinc homeostasis are substantial and correlate with the severity of the disease, suggesting that zinc might also be useful as a diagnostic marker for evaluating the severity and predicting the outcome of sepsis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.