Evidence map›Paper›PMID 30060466›Full record

ArticleMolecules (Basel, Switzerland)2018

Be Aware of Aggregators in the Search for Potential Human

Lucas G Viviani, Erika Piccirillo, Arquimedes Cheffer, Leandro de Rezende, Henning Ulrich, Ana Maria Carmona-Ribeiro, Antonia T-do Amaral

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. RNase P Inhibitors Identified as Aggregators.Antimicrobial agents and chemotherapy · 2021
    Article
  3. Article
  4. Article
  5. Molecular Modeling in Drug Design.Molecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucas G VivianiDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo 05508-000, Brazil. lucas.viviani@usp.br.ORCID 0000-0002-4767-4825
Erika PiccirilloDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo 05508-000, Brazil. erika@iq.usp.br.ORCID 0000-0003-4094-3102
Arquimedes ChefferDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo 05508-000, Brazil. arquiqbq@iq.usp.br.
Leandro de RezendeDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo 05508-000, Brazil. lrezende@iq.usp.br.
Henning UlrichDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo 05508-000, Brazil. henning@iq.usp.br.
Ana Maria Carmona-RibeiroDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo 05508-000, Brazil. mcribeir@iq.usp.br.ORCID 0000-0001-8500-2707
Antonia T-do AmaralDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, São Paulo 05508-000, Brazil. atdamara@iq.usp.br.ORCID 0000-0003-2937-5255

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Promiscuous inhibition due to aggregate formation has been recognized as a major concern in drug discovery campaigns. Here, we report some aggregators identified in a virtual screening (VS) protocol to search for inhibitors of human

Indexed as

5'-NucleotidaseComputer SimulationDatabases, ChemicalDrug Evaluation, PreclinicalDynamic Light ScatteringEnzyme InhibitorsFalse Positive ReactionsGPI-Linked ProteinsHumansInhibitory Concentration 50Nephelometry and TurbidimetryProtein Aggregates5'-NucleotidaseEnzyme InhibitorsGPI-Linked ProteinsNT5E protein, humanProtein Aggregatesaggregationdynamic light scatteringenzymatic assayshuman ecto-5′-nucleotidasepromiscuous mechanismturbidimetryvirtual screening

Identifiers

PMID30060466
PMCPMC6222861

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.