ArticleJournal of clinical medicine2018
Predictions of Preterm Birth from Early Pregnancy Characteristics: Born in Guangzhou Cohort Study.
Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- First-Trimester Prediction Models Based on Maternal Characteristics for Adverse Pregnancy Outcomes: A Systematic Review and Meta-Analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- Prognostic prediction models for adverse birth outcomes: A systematic review.Journal of global health · 2024Pooled it
- The China Birth Cohort-Environmental and Genetic Factors (CBC-EG) Study: Design, Aims, Protocol, Findings, and Prospects.Environment & health (Washington, D.C.) · 2026Review
- Maternal, obstetric and gynecological factors associated with preterm birth in Rwanda: findings from a national longitudinal study.BMC pregnancy and childbirth · 2023Article
- Impact of socioeconomic factors and health determinants on preterm birth in Brazil: a register-based study.BMC pregnancy and childbirth · 2022Article
- Technology-free predictors of preterm birth in singleton women with threatened preterm labor: a prospective cohort study.BMC pregnancy and childbirth · 2022Article
- Article
- Blood pressure trajectories during pregnancy and preterm delivery: A prospective cohort study in China.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Prevalence of low birth weight and its associated factors: Hospital based cross sectional study in Nepal.PLOS global public health · 2022Article
- Data-driven risk stratification for preterm birth in Brazil: a population-based study to develop of a machine learning risk assessment approach.Lancet regional health. Americas · 2021Article
- Risk assessment of preterm birth through identification and stratification of pregnancies using a real-time scoring algorithm.SAGE open medicine · 2021Article
- Factors Associated with Singleton Preterm Birth in Shire Suhul General Hospital, Northern Ethiopia, 2018.Journal of pregnancy · 2019Article
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Authors and funding
19 authors.
Funding
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Abstract
Preterm birth (PTB, <37 weeks) is the leading cause of death in children <5 years of age. Early risk prediction for PTB would enable early monitoring and intervention. However, such prediction models have been rarely reported, especially in low- and middle-income areas. We used data on a number of easily accessible predictors during early pregnancy from 9044 women in Born in Guangzhou Cohort Study, China to generate prediction models for overall PTB and spontaneous, iatrogenic, late (34⁻36 weeks), and early (<34 weeks) PTB. Models were constructed using the Cox proportional hazard model, and their performance was evaluated by Harrell's c and D statistics and calibration plot. We further performed a systematic review to identify published models and validated them in our population. Our new prediction models had moderate discrimination, with Harrell's c statistics ranging from 0.60⁻0.66 for overall and subtypes of PTB. Significant predictors included maternal age, height, history of preterm delivery, amount of vaginal bleeding, folic acid intake before pregnancy, and passive smoking during pregnancy. Calibration plots showed good fit for all models except for early PTB. We validated three published models, all of which were from studies conducted in high-income countries; the area under receiver operating characteristic for these models ranged from 0.50 to 0.56. Based on early pregnancy characteristics, our models have moderate predictive ability for PTB. Future studies should consider inclusion of laboratory markers for the prediction of PTB.
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