Evidence map›Paper›PMID 30060206›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2019

Incidence of new-onset diabetes mellitus and association with mortality in childhood solid organ transplant recipients: a population-based study.

Rahul Chanchlani, Sang Joseph Kim, Stephanie N Dixon, Vanita Jassal, Tonny Banh, Karlota Borges, Jovanka Vasilevska-Ristovska, John Michael Paterson, Vicky Ng, Anne Dipchand and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Rahul ChanchlaniDepartment of Pediatrics, Division of Pediatric Nephrology, Hospital for Sick Children, Toronto, ON, Canada.
Sang Joseph KimInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Stephanie N DixonInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Vanita JassalDepartment of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada.
Tonny BanhChild Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Karlota BorgesChild Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
Jovanka Vasilevska-RistovskaChild Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, ON, Canada.
John Michael PatersonInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Vicky NgDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, ON, Canada.
Anne DipchandDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Melinda SolomonDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Diane HebertDepartment of Pediatrics, Division of Pediatric Nephrology, Hospital for Sick Children, Toronto, ON, Canada.
Rulan S ParekhDepartment of Pediatrics, Division of Pediatric Nephrology, Hospital for Sick Children, Toronto, ON, Canada.
Hospital for Sick Children · CASickKids Foundation · CAUniversity Health Network · CAUniversity of Toronto · CAInstitute for Clinical Evaluative Sciences · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrecise estimates of the long-term risk of new-onset diabetes and its impact on mortality among transplanted children are not known.

methodsWe conducted a cohort study comparing children undergoing solid organ (kidney, heart, liver, lung and multiple organ) transplant (n = 1020) between 1991 and 2014 with healthy non-transplanted children (n = 7 134 067) using Ontario health administrative data. Outcomes included incidence of diabetes among transplanted and non-transplanted children, the relative hazard of diabetes among solid organ transplant recipients, overall and at specific intervals posttransplant, and mortality among diabetic transplant recipients.

resultsDuring 56 019 824 person-years of follow-up, the incidence rate of diabetes was 17.8 [95% confidence interval (CI) 15-21] and 2.5 (95% CI 2.5-2.5) per 1000 person-years among transplanted and non-transplanted children, respectively. The transplant cohort had a 9-fold [hazard ratio (HR) 8.9; 95% CI 7.5-10.5] higher hazard of diabetes compared with those not transplanted. Risk was highest within the first year after transplant (HR 20.7; 95% CI 15.9-27.1), and remained elevated even at 5 and 10 years of follow-up. Lung and multiple organ recipients had a 5-fold (HR 5.4; 95% CI 3.0-9.8) higher hazard of developing diabetes compared with kidney transplant recipients. Transplant recipients with diabetes had a three times higher hazard of death compared with those who did not develop diabetes (HR 3.3; 95% CI 2.3-4.8).

conclusionsThe elevated risk of diabetes in transplant recipients persists even after a decade, highlighting the importance of ongoing surveillance. Diabetes after transplantation increases the risk of mortality among childhood transplant recipients.

Indexed as

AdolescentAge of OnsetChildChild, PreschoolCohort StudiesDiabetes MellitusFemaleHumansIncidenceInfantInfant, NewbornMaleOntarioOrgan TransplantationRisk FactorsTransplant Recipientsadministrative databasescohort studydeathincidenceoutcomes

Identifiers

PMID30060206
PMCPMC6399486
OpenAlexW2887051752

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.