ArticleAmerican journal of epidemiology2018
Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Using Epigenetic Clocks to Characterize Biological Aging in Studies of Children and Childhood Exposures: a Systematic Review.Prevention science : the official journal of the Society for Prevention Research · 2023Pooled it
- How are social determinants of health integrated into epigenetic research? A systematic review.Social science & medicine (1982) · 2021Pooled it
- The Effect of the Earned Income Tax Credit on Physical and Mental health-Results from the Atlanta Paycheck Plus Experiment.The Milbank quarterly · 2024Trial
- Article
- Employment trajectories and biological aging: Racial and ethnic disparities in work instability and epigenetic age acceleration.SSM - population health · 2026Article
- How education gets under the skin: Pathways linking educational advantage to slower biological aging.Social science & medicine (1982) · 2026Article
- Childhood socioeconomic status and changes in biological aging across mid-to-later life.Social science & medicine (1982) · 2026Article
- Systematic investigation of interindividual variation of DNA methylation in human whole blood.Genome biology · 2026Article
- Associations among prenatal stress, socioeconomic status, and infant epigenetic aging.Psychoneuroendocrinology · 2025Article
- Impact of socioeconomic conditions across the life course on epigenetic age acceleration: evidence from a longitudinal cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Article
- The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Predictive power of epigenetic age - opportunities and cautions.Epigenomics · 2025Article
- Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing.GeroScience · 2025Review
- The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives.GeroScience · 2025Review
- Greater residential greenness is associated with reduced epigenetic aging in adults.Scientific reports · 2025Article
- Differing Effects of Alcohol Use on Epigenetic and Brain Age in Adult Children of Parents with Alcohol Use Disorder.Brain sciences · 2024Article
- Life-Course Socioeconomic Trajectories and Biological Aging: The Importance of Lifestyles and Physical Wellbeing.Nutrients · 2024Article
- Lifetime employment trajectories and cancer.Scientific reports · 2024Article
- Parental Divorce in Childhood and the Accelerated Epigenetic Aging for Earlier and Later Cohorts: Role of Mediators of Chronic Depressive Symptoms, Education, Smoking, Obesity, and Own Marital Disruption.Journal of population ageing · 2024Article
9 more citing papers are in PubMed but not listed here.
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Abstract
Accelerated DNA methylation age is linked to all-cause mortality and environmental factors, but studies of associations with socioeconomic position are limited. Researchers generally use small selected samples, and it is unclear how findings obtained with 2 commonly used methods for calculating methylation age (the Horvath method and the Hannum method) translate to general population samples including younger and older adults. Among 1,099 United Kingdom adults aged 28-98 years in 2011-2012, we assessed the relationship of Horvath and Hannum DNA methylation age acceleration with a range of social position measures: current income and employment, education, income and unemployment across a 12-year period, and childhood social class. Accounting for confounders, participants who had been less advantaged in childhood were epigenetically "older" as adults: In comparison with participants who had professional/managerial parents, Hannum age was 1.07 years higher (95% confidence interval: 0.20, 1.94) for participants with parents in semiskilled/unskilled occupations and 1.85 years higher (95% confidence interval: 0.67, 3.02) for those without a working parent at age 14 years. No other robust associations were seen. Results accord with research implicating early life circumstances as critical for DNA methylation age in adulthood. Since methylation age acceleration as measured by the Horvath and Hannum estimators appears strongly linked to chronological age, researchers examining associations with the social environment must take steps to avoid age-related confounding.
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