ArticleAmerican journal of epidemiology2018
Estimating the Relative Excess Risk Due to Interaction in Clustered-Data Settings.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01310023 (Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women
Who cites it
29 citing papers in PubMed.
- The Nicotine Metabolite Ratio and Response to Smoking Cessation Treatment Among People Living with HIV Who Smoke in South Africa.International journal of environmental research and public health · 2025Trial
- Interaction between clinical and genetic risk of atrial fibrillation in the danish diet, cancer and health cohort.Open heart · 2026Article
- Ambient Air Pollution, Preconceptional Thyrotropin Abnormalities, and the Risk of Preterm Birth: A Nationwide Chinese Cohort Study.Environment & health (Washington, D.C.) · 2026Article
- Minimum combined sleep, physical activity, and nutrition variations associated with lifeSPAN and healthSPAN improvements: a population cohort study.EClinicalMedicine · 2026Article
- The independent association and interactive effect of nutritional deficiency and poor sleep quality on cognitive decline in older adults.BMC public health · 2026Article
- Interactive effect of social isolation and poor nutritional status on cognitive function decline in older adults.Frontiers in nutrition · 2026Article
- Article
- The independent association of social isolation and loneliness with cognitive frailty in Chinese older adults: a cross-sectional study.BMC public health · 2025Article
- Ambient biothermal stress, preconceptional thyrotropin abnormalities, and the risk of preterm birth: a nationwide Chinese cohort study.Nature communications · 2025Article
- REACH-OUT: Race, Ethnicity, and Air Pollution in COVID-19 Hospitalization OUTcomes.Research report (Health Effects Institute) · 2025Article
- Widowhood disparities in nonaccidental mortality attributable to heat waves and ozone.Eco-Environment & Health · 2025Article
- Postpartum kidney disease associated with placental abruption: a population-based retrospective cohort study.Lancet regional health. Americas · 2025Article
- Joint Effect of Inflammatory Dietary Patterns and Physical Activity on the Risk of Depressive Symptoms: A Nation-Wide Cross-Sectional Study.Yonsei medical journal · 2025Article
- The Individual and Combined Effects of Prenatal Micronutrient Supplementations on Neurobehavioral Developmental Disorders in Preschool Children.Children (Basel, Switzerland) · 2025Article
- Association of spontaneous abortion and lifestyle with diabetes mellitus in women: a cross-sectional study in UK Biobank.BMC pregnancy and childbirth · 2025Article
- Associations between short-term exposure to fine particulate matter with ischemic stroke mortality and the role of green space: a time-series study in Zibo, China.Journal of global health · 2025Article
- Joint Effect of Central Obesity and Family History on Hypertension in Type 2 Diabetes: A Cross-Sectional Study in China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Triglyceride-glucose index and its additive interaction withAnnals of medicine · 2024Article
- White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Risks of Placental Abruption and Preterm Delivery in Patients Undergoing Assisted Reproduction.JAMA network open · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The risk difference scale is often of primary interest when evaluating public health impacts of interventions on binary outcomes. However, few investigators report findings in terms of additive interaction, probably because the models typically used for binary outcomes implicitly measure interaction on the multiplicative scale. One measure with which to assess additive interaction from multiplicative models is the relative excess risk due to interaction (RERI). The RERI measure has been applied in many contexts, but one limitation of previous approaches is that clustering in data has rarely been considered. We evaluated the RERI metric for the setting of clustered data using both population-averaged and cluster-conditional models. In simulation studies, we found that estimation and inference for the RERI using population-averaged models was straightforward. However, frequentist implementations of cluster-conditional models including random intercepts often failed to converge or produced degenerate variance estimates. We developed a Bayesian implementation of log binomial random-intercept models, which represents an attractive alternative for estimating the RERI in cluster-conditional models. We applied the methods to an observational study of adverse birth outcomes in mothers with human immunodeficiency virus, in which mothers were clustered within clinical research sites.
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