ArticleGenome biology and evolution2018
Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 1768.
Article in Genome biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
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- Genetic Diversity of Human Fungal Pathogens.Current clinical microbiology reports · 2023Article
- Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease.PLoS biology · 2023Article
- Comprehensive whole genome sequencing with hybrid assembly of multi-drug resistantCurrent research in microbial sciences · 2023Article
- Lycopene, Mesoporous Silica Nanoparticles and Their Association: A Possible Alternative against Vulvovaginal Candidiasis?Molecules (Basel, Switzerland) · 2022Article
- Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain ofHeliyon · 2022Article
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- Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model.Journal of fungi (Basel, Switzerland) · 2021Article
- Interstrain Variability of Human VaginalMolecules (Basel, Switzerland) · 2021Article
- Long-Reads-Based Metagenomics in Clinical Diagnosis With a Special Focus on Fungal Infections.Frontiers in microbiology · 2021Review
- The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity inFrontiers in microbiology · 2020Article
- GPI0363 inhibits the interaction of RNA polymerase with DNA inRSC advances · 2019Article
- Phased Diploid Genome Assemblies for Three Strains ofG3 (Bethesda, Md.) · 2019Article
- Complete Genome Sequence ofFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans TIMM1768 is a highly virulent strain utilized as a model organism for the study of gastrointestinal and oral candidiasis. Despite being a model strain, identification of its genetic determinants of pathogenesis is hindered by the unavailability of its genome sequence. In this study, we determined the genome sequence of C. albicans TIMM1768 using reads obtained from portable MinION and benchtop Ion PGM sequencers. Genome annotation and a comparative analysis with published genomes revealed that the TIMM1768 strain was close to Candida albicans CHN1, and we identified a significant number of genes encoding for pathogenesis. The availability of the C. albicans TIMM1768 genome will facilitate comparative genomic analysis of Candida species, including studies of its virulence mechanisms and the development of treatment strategies for severe candidiasis.
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