ArticleEnvironmental research2018
Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile.
Article in Environmental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Association of Blood Arsenic Concentrations with Lipid Markers in Uruguayan Adolescents: Exploring Effect Modification by Body Mass Index and Sex.Exposure and health · 2026Article
- Unraveling the role of OsPIP1;3 in arsenic transport in rice (Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Arsenic in drinking water and breast cancer: a case-control study from a high exposure area in Northern Chile.Breast cancer research and treatment · 2025Article
- Metabolic Derangement by Arsenic: a Review of the Mechanisms.Biological trace element research · 2024Review
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches.Toxics · 2023Review
- An appraisal of the principal concerns and controlling factors for Arsenic contamination in Chile.Scientific reports · 2023Article
- Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases.Apoptosis : an international journal on programmed cell death · 2023Review
- Intergenerational arsenic exposure on the mouse epigenome and metabolic physiology.Environmental and molecular mutagenesis · 2023Article
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- Analysis of gut bacteriome ofFrontiers in microbiology · 2023Article
- Relationship Between Serum Levels of Arsenic, Cadmium, and Mercury and Body Mass Index and Fasting Plasma Glucose in a Mexican Adult Population.Biological trace element research · 2022Article
- An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Article
- Understanding exposures and latent disease risk within the National Institute of Environmental Health Sciences Superfund Research Program.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues.Antioxidants (Basel, Switzerland) · 2022Review
- Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms.Frontiers in endocrinology · 2022Review
- Arsenic and Obesity: a Review of Causation and Interaction.Current environmental health reports · 2020Review
- Arsenic Exposure and Glucose Metabolism: Experimental Studies Suggest Implications for Type 2 Diabetes.Environmental health perspectives · 2020Article
- Chronic arsenic exposure impairs adaptive thermogenesis in male C57BL/6J mice.American journal of physiology. Endocrinology and metabolism · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe prevalence of type 2 diabetes (T2D) has nearly doubled since 1980. Elevated body mass index (BMI) is the leading risk factor for T2D, mediated by inflammation and oxidative stress. Arsenic shares similar pathogenic processes, and may contribute to hyperglycemia and β-cell dysfunction.
objectivesWe assessed a unique situation of individuals living in Northern Chile with data on lifetime arsenic exposure to evaluate the relationship between arsenic and T2D, and investigate possible interactions with BMI.
methodsWe analyzed data collected from October 2007-December 2010 from an arsenic-cancer case-control study. Information on self-reported weight, height, smoking, diet, and other factors were obtained. Diabetes was defined by self-reported physician-diagnoses or use of hypoglycemic medication. A total of 1053 individuals, 234 diabetics and 819 without known diabetes were included.
resultsThe T2D odds ratio (OR) for cumulative arsenic exposures of 610-5279 and ≥ 5280 μg/L-years occurring 40 years or more before interview were 0.97 (95% CI: 0.66-1.43) and 1.53 (95% CI: 1.05-2.23), respectively. Arsenic-associated T2D ORs were greater in subjects with increased BMIs. For example, the ORs for past cumulative exposures ≥ 5280 μg/L-years was 1.45 (95% CI: 0.74-2.84) in participants with BMIs < 25 kg/m
conclusionsThese findings identify increased odds of T2D with arsenic exposure, which are significantly increased in individuals with excess BMI.
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