Evidence map›Paper›PMID 30059754›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2018

Design and biological activity of novel stealth polymeric lipid nanoparticles for enhanced delivery of hydrophobic photodynamic therapy drugs.

Mathias Viard, Henry Reichard, Bruce A Shapiro, Farukh A Durrani, Aimee J Marko, R Michelle Watson, Ravindra K Pandey, Anu Puri

Open access · greenAbstract read
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mathias ViardRNA Structure and Design Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, U.S.A.; Leidos Biomedical Research Inc., Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, U.S.A.
Henry ReichardRNA Structure and Design Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, U.S.A.
Bruce A ShapiroRNA Structure and Design Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, U.S.A.
Farukh A DurraniPhotodynamic Therapy Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.
Aimee J MarkoPhotodynamic Therapy Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.
R Michelle WatsonPhotodynamic Therapy Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.
Ravindra K PandeyPhotodynamic Therapy Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.. Electronic address: Ravindra.Pandey@RoswellPark.org.
Anu PuriRNA Structure and Design Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, U.S.A.. Electronic address: puria@mail.nih.gov.
Roswell Park Comprehensive Cancer Center · USFrederick National Laboratory for Cancer Research · USLeidos (United States) · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Computational RNA NanodesignZIABC011061 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SHAPIRO, BRUCE · 2009 to 2021
$12.3M
Novel Cancer Nanotechnology Platforms for Photodynamic Therapy and ImagingR01CA119358 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI PANDEY, RAVINDRA K. · 2005 to 2009
$3.2M
COMPUTER ANALYSIS OF NUCLEIC ACID STRUCTUREZ01BC008382 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SHAPIRO, BRUCE A. · 1996 to 2008
$1.2M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z01 BC008382NCI NIH HHS HHSN261200800001ENCI NIH HHS P30 CA016056NCI NIH HHS R01 CA119358NIH HHS P30CA16056
6 · The paper itself

Abstract

Advances in in vivo stability and preferential tumor uptake of cancer nanomedicine are warranted for effective chemotherapy. Here, we describe a novel nanoformulation using an unconventional polymeric tubule-forming phospholipid, DC

Indexed as

Drug Delivery SystemsPhotochemotherapyAdenocarcinomaAnimalsApoptosisCell ProliferationColorectal NeoplasmsDrug CarriersHumansHydrophobic and Hydrophilic InteractionsMiceMice, Inbred BALB CMice, NudeNanoparticlesPhospholipidsPhotosensitizing AgentsDrug CarriersPhospholipidsPhotosensitizing AgentsPolymersDrug deliveryHydrophobic drugsLipidic stealth nanoparticlesPhotodynamic therapy

Identifiers

PMID30059754
PMCPMC8034484
OpenAlexW2884408344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.