Evidence map›Paper›PMID 30059656›Full record

ArticleThe American journal of pathology2018

Removal of Pre-Existing Periodontal Inflammatory Condition before Tooth Extraction Ameliorates Medication-Related Osteonecrosis of the Jaw-Like Lesion in Mice.

Terresa Kim, Sol Kim, Minju Song, Cindy Lee, Hideo Yagita, Drake W Williams, Eric C Sung, Christine Hong, Ki-Hyuk Shin, Mo K Kang and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Terresa KimThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California.
Sol KimThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California.
Minju SongThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California; School of Dentistry, Dankook University, Cheonan, Republic of Korea.
Cindy LeeThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California.
Hideo YagitaDepartment of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Drake W WilliamsThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California.
Eric C SungSection of Special Patient Care, UCLA School of Dentistry, University of California, Los Angeles, Los Angeles, California.
Christine HongSection of Orthodontics, UCLA School of Dentistry, University of California, Los Angeles, Los Angeles, California.
Ki-Hyuk ShinThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California; UCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California.
Mo K KangThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California; UCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California.
No-Hee ParkThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California; UCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California.
Reuben H KimThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, California; UCLA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. Electronic address: rkim@dentistry.ucla.edu.
University of California, Los Angeles · USJuntendo University · JP

Funding

Molecular mechanisms of drug-induced ONJ and osteomucosal chronic woundsR01DE023348 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIM, REUBEN HAN-KYU · 2013 to 2017
$1.9M
Promoting DMSC-mediated craniofacial regeneration by estrogenK08DE024603 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HONG, CHRISTINE · 2014 to 2018
$666k
Role of pro-inflammatory cytokines in drug induced osteonecrosis of the jawF30DE025172 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WILLIAMS, DRAKE WINSLOW · 2015 to 2019
$220k
NIDCR NIH HHS F30 DE025172NIDCR NIH HHS K08 DE024603NIDCR NIH HHS R01 DE023348
6 · The paper itself

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but detrimental intraoral lesion that predominantly occurs in patients with long-term use of antiresorptive agents, such as bisphosphonate and denosumab, a human anti-receptor activator of NF-κB ligand (RANKL) monoclonal antibody (Ab). Surgical intervention, such as tooth extraction, is a known risk factor for MRONJ, which is often performed to eliminate preexiting pathologic inflammatory conditions, such as periodontal diseases. Nonetheless, it remains unknown whether pre-existing periodontal disease condition exacerbates, or removal of such condition ameliorates, MRONJ development after tooth extraction. In this study, we combined the ligature-induced periodontitis and the tooth extraction mouse models under the administration of zoledronic acid (ZOL) or anti-RANKL Ab, and provide experimental evidence that a pre-existing pathologic inflammatory condition exacerbates MRONJ development after tooth extraction in mice. Under ZOL administration, tooth extraction alone induced ONJ lesions; however, extraction of a ligature-placed tooth further exacerbated ONJ development. When the ligature was removed and the inflammatory condition was deescalated, ONJ development was ameliorated. Anti-RANKL Ab administration resulted in similar outcomes. Interestingly, unlike ZOL-administered mice, anti-RANKL Ab-administered mice exhibited complete absence of osteoclasts, suggesting that physical presence of osteoclasts is not directly involved in ONJ development. Collectively, our study demonstrated that periodontal disease is a functionally linked risk factor that predisposes ONJ development after tooth extraction in the presence of bisphosphonate and denosumab.

Indexed as

Tooth ExtractionAnimalsBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsDenosumabDisease Models, AnimalFemaleJaw DiseasesLigationMice, Inbred C57BLOsteonecrosisPeriodontitisBone Density Conservation AgentsDenosumab

Identifiers

PMID30059656
PMCPMC6169128
OpenAlexW2884212122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.