ArticlePLoS neglected tropical diseases2018
Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- The biting rate of Aedes aegypti and its variability: A systematic review (1970-2022).PLoS neglected tropical diseases · 2023Pooled it
- Dynamical modeling and analysis of the impact of zonal prevention and control under normalized management on African Swine Fever transmission in China.Infectious Disease Modelling · 2026Article
- Phylogeny ofParasite epidemiology and control · 2026Article
- Metagenomic Exploration of the Bacteriome Reveals Natural Wolbachia Infections in Yellow Fever Mosquito Aedes aegypti and Asian Tiger Mosquito Aedes albopictus.Current microbiology · 2026Article
- Control of Aedes albopictus populations by silencing of the vesicular GABA transporter (vgat) and the vesicular monoamine transporter (vmat) genes using recombinant Chlorella shRNA.Parasites & vectors · 2025Article
- Silencing theInsects · 2025Article
- Holobiont-holobiont interactions across host-ectoparasite systems.Parasites & vectors · 2025Review
- Research trends and hotspots in viral neglected tropical diseases: a bibliometric analysis.Future microbiology · 2025Article
- Exploring Zika's dynamics: A scoping review journey from epidemic to equations through mathematical modelling.Infectious Disease Modelling · 2025Review
- Efficacy of Wolbachia-based mosquito control: Predictions of a spatially discrete mathematical model.PloS one · 2024Article
- Modelling the transmission of dengue, zika and chikungunya: a scoping review protocol.BMJ open · 2023Article
- Modeling Sustained Transmission ofTropical medicine and infectious disease · 2023Article
- Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains.Scientific reports · 2022Article
- Indole alkaloids inhibit zika and chikungunya virus infection in different cell lines.BMC complementary medicine and therapies · 2021Article
- Development of an RNAi-based microalgal larvicide for the control of Aedes aegypti.Parasites & vectors · 2021Article
- Reducing dengue fever cases at the lowest budget: a constrained optimization approach applied to Thailand.BMC public health · 2021Article
- Vector dynamics influence spatially imperfect genetic interventions against disease.Evolution, medicine, and public health · 2021Article
- Vector Competence for DENV-2 AmongFrontiers in cellular and infection microbiology · 2021Article
- Superinfection Exclusion in Mosquitoes and Its Potential as an Arbovirus Control Strategy.Viruses · 2020Review
- Modeling the potential of wAu-Wolbachia strain invasion in mosquitoes to control Aedes-borne arboviral infections.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
Once Aedes aegypti and Aedes albopictus mosquitoes that spread Chikungunya virus, dengue virus, and Zika virus are infected with Wolbachia, they have reduced egg laying rates, reduced transmission abilities, and shorter lifespans. Since most infected mosquitoes are only infectious in the last few days of their lives, shortening a mosquito's lifespan by a day or two can greatly reduce their abilities to spread mosquito-borne viral diseases, such as Chikungunya, dengue fever, and Zika. We developed a mathematical model to compare the effectiveness of the wMel and wAlbB strains of Wolbachia for controlling the spread of these viruses. The differences among the diseases, mosquitoes, and Wolbachia strains are captured by the model parameters for the mosquito-human transmission cycle. Moreover, the model accounts for the behavior changes of infectious population created by differences in the malaise caused by these viruses. We derived the effective and basic reproduction numbers for the model that are used to estimate the number of secondary infections from the infectious populations. In the same density of Wolbachia-free Aedes aegypti or Aedes albopictus mosquitoes, we observed that wMel and wAlbB strains of Wolbachia can reduce the transmission rates of these diseases effectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.