ArticlePLoS neglected tropical diseases2018
Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 28 citations in OpenAlex.
- Systems analysis of subjects acutely infected with the Chikungunya virus.PLoS pathogens · 2019Trial
- Outbreak investigation of reemerging chikungunya virus in Malaysia in 2019-2020.BMC infectious diseases · 2026Article
- Hospitalizations associated with endemic and non-endemic mosquito-borne arboviruses in Canada, 2002-2023.PloS one · 2026Article
- Chikungunya virus: Current situation and future challenges.Biosafety and health · 2025Review
- Chikungunya virus and other emerging arthritogenic alphaviruses.Nature reviews. Microbiology · 2025Review
- Article
- Molecular and biological characterization of an Asian-American isolate of Chikungunya virus.PloS one · 2022Article
- Genetic Diversity and Spatiotemporal Dynamics of Chikungunya Infections in Mexico during the Outbreak of 2014-2016.Viruses · 2021Article
- Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018.PLoS neglected tropical diseases · 2021Article
- Evolution and epidemiologic dynamics of dengue virus in Nicaragua during the emergence of chikungunya and Zika viruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Rediscovering the chikungunya virusBiomedica : revista del Instituto Nacional de Salud · 2021Review
- Article
- Chikungunya virus infections in Finnish travellers 2009-2019.Infection ecology & epidemiology · 2020Article
- Genomic Epidemiology as a Public Health Tool to Combat Mosquito-Borne Virus Outbreaks.The Journal of infectious diseases · 2020Review
- Article
- El Niño Southern Oscillation, overseas arrivals and imported chikungunya cases in Australia: A time series analysis.PLoS neglected tropical diseases · 2019Article
- Peptide arrays incubated with three collections of human sera from patients infected with mosquito-borne viruses.F1000Research · 2019Article
- Inhibition by Marine Algae of Chikungunya Virus Isolated From Patients in a Recent Disease Outbreak in Rio de Janeiro.Frontiers in microbiology · 2019Article
- Evolutionary analysis of the Chikungunya virus epidemic in Mexico reveals intra-host mutational hotspots in the E1 protein.PloS one · 2018Article
- Demystifying therapeutic potential of medicinal plants against chikungunya virus.Indian journal of pharmacologyReview
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Authors and funding
19 authors at 7 institutions in 2 countries.
Funding
Abstract
Chikungunya virus (CHIKV) has been detected sporadically since the 1950s and includes three distinct co-circulating genotypes. In late 2013, the Asian genotype of CHIKV was responsible for the Caribbean outbreak (CO) that rapidly became an epidemic throughout the Americas. There is a limited understanding of the molecular evolution of CHIKV in the Americas during this epidemic. We sequenced 185 complete CHIKV genomes collected mainly from Nicaragua in Central America and Florida in the United States during the 2014-2015 Caribbean/Americas epidemic. Our comprehensive phylogenetic analyses estimated the epidemic history of the Asian genotype and the recent Caribbean outbreak (CO) clade, revealed considerable genetic diversity within the CO clade, and described different epidemiological dynamics of CHIKV in the Americas. Specifically, we identified multiple introductions in both Nicaragua and Florida, with rapid local spread of viruses in Nicaragua but limited autochthonous transmission in Florida in the US. Our phylogenetic analysis also showed phylogeographic clustering of the CO clade. In addition, we identified the significant amino acid substitutions that were observed across the entire Asian genotype during its evolution and examined amino acid changes that were specific to the CO clade. Deep sequencing analysis identified specific minor variants present in clinical specimens below-consensus levels. Finally, we investigated the association between viral phylogeny and geographic/clinical metadata in Nicaragua. To date, this study represents the largest single collection of CHIKV complete genomes during the Caribbean/Americas epidemic and significantly expands our understanding of the emergence and evolution of CHIKV CO clade in the Americas.
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