ArticleThe Journal of craniofacial surgery2018
Persistent Opioid Use Among Children, Adolescents, and Young Adults After Common Cleft Operations.
Article in The Journal of craniofacial surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Prolonged opioid use after surgery in children, adolescents, and young adults: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Pooled it
- Incidence and risk factors of new persistent opioid use after surgery and trauma: A systematic review.BMC surgery · 2024Pooled it
- A Prospective Analysis of Opioid Prescription, Consumption, and Psychometric Correlations in Outpatient Plastic Surgery Procedures.Plastic surgery (Oakville, Ont.) · 2025Article
- Reducing Postoperative Opioids in Pediatric Orthopaedics: An Updated Tiered Prescription Guideline with a "Tier 0".Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Association of Patient-Reported Anxiety and Pain After Alveolar Bone Grafting.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2024Article
- Medical marijuana access and prolonged opioid use among adolescents and young adults.The American journal on addictions · 2023Article
- Improved postoperative recovery profile in pediatric oral rehabilitation with low-dose dexmedetomidine as an opioid substitute for general anesthesia: a randomized double-blind clinical trial.Journal of dental anesthesia and pain medicine · 2022Article
- Prolonged Opioid Use following Hand Surgery: A Systematic Review and Proposed Criteria.Plastic and reconstructive surgery. Global open · 2022Article
- Surgeon feedback to decrease opioid prescriptions after pediatric appendectomy.World journal of pediatric surgery · 2022Article
- Opioid use disorder and overdose among youth following an initial opioid prescription.Addiction (Abingdon, England) · 2021Article
- Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings.Paediatric drugs · 2021Review
- Effective Reduction in Opioid Prescriptions for Ambulatory Lesion Excisions in Pediatric Patients.Plastic and reconstructive surgery. Global open · 2021Article
- The Impact of Nonpharmacological Interventions on Patient Experience, Opioid Use, and Health Care Utilization in Adult Cardiac Surgery Patients: Protocol for a Mixed Methods Study.JMIR research protocols · 2021Article
- Cancer survivorship and its association with perioperative opioid use for minor non-cancer surgery.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Incidence of and Factors Associated With Prolonged and Persistent Postoperative Opioid Use in Children 0-18 Years of Age.Anesthesia and analgesia · 2020Article
- Increased risk of new persistent opioid use in pediatric and young adult patients with kidney stones.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Article
- Basics and Best Practices of Multimodal Pain Management for the Plastic Surgeon.Plastic and reconstructive surgery. Global open · 2020Review
- New-onset persistent opioid use following breast cancer treatment in older adult women.Cancer · 2020Article
- Risk of Opioid Use Disorder from Exposure to Opioids in the Perioperative Period: A Systematic Review.Anesthesiology and pain medicine · 2020Article
- Association of Opioid Prescribing Patterns With Prescription Opioid Overdose in Adolescents and Young Adults.JAMA pediatrics · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSurgical care represents an important source of opioid prescribing and chronic use, but rates of prolonged opioid use following pediatric procedures remain unclear. The authors describe the rates and risk factors for new persistent opioid use in patients after common cleft operations.
methodsThe authors examined claims from the Truven Marketscan databases from January 1, 2010 to December 31, 2014. The authors included opioid-naive patients ages 8 to 25, who underwent 1 of 10 cleft-related procedures. Patients were considered opioid-naïve if they had no opioid prescription fills in the 11 months prior to the perioperative period. The authors obtained a random sample of age-matched, nonsurgical patients from the same dataset to be used as a control group. Included cleft patients had no procedural codes in the 6 months following surgery. All included patients filled an opioid prescription during the perioperative period, defined as 30 days before and 14 days after surgery. The primary outcome was new persistent opioid use, which is defined as continued opioid prescription fills between 90 and 180 days after the procedure.
resultsThis cohort included 2039 cleft patients and 2100 control patients. The incidence of new persistent opioid use following surgery was 4.4% and 0.1% in the control group. Higher odds of opioid use 3 months beyond surgery were associated with distractor placement (OR 5.34, CI 2.00-14.24, P = 0.001). Increasing age (OR 1.11, CI 1.04-1.17, P = 0.001) and presence of a gastrointestinal comorbidity (OR 7.37, CI 1.49-36.54, P = 0.014) were also associated with new persistent use.
conclusionsNew persistent opioid use occurs after cleft-related procedures and could lead to chronic use in children, adolescents, and young adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.