ArticleAdipocyte2018
Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats.
Article in Adipocyte, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Cold induces increased ad libitum energy intake independent of changes in energy expenditure: a controlled crossover trial in adults.The American journal of clinical nutrition · 2025Trial
- Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity.Metabolites · 2023Review
- Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers.International journal of biological sciences · 2022Review
- Intercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications.Journal of molecular cell biology · 2021Review
- Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ.International journal of molecular sciences · 2021Article
- Adapting to the Cold: A Role for Endogenous Fibroblast Growth Factor 21 in Thermoregulation?Frontiers in endocrinology · 2020Review
- Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing.Nutrients · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effects of cold acclimation on circulating fibroblast growth factor 21 (FGF21) levels, as well as its production and signaling in classical brown and white adipose tissues. Male Wistar rats were cold (4°C) acclimatized for 7 days. Subsequently, liver, interscapular and aortic BAT (iBAT and aBAT), and the Sc Ing and epididymal (Epid) white adipose tissues were extracted. Cold acclimation significantly reduced circulating FGF21 and its liver expression. Conversely, FGF21 content increased in iBAT, aBAT and Sc Ing fat depots, along with the expressions of the Fgf21 receptor and the receptor co-factor β-klotho. Cold acclimation increased FGF21 secretion from Sc Ing and Epid adipocytes, although only iBAT and Sc Ing fat depots enhanced ERK1/2 phosphorylation. These findings provide evidence that FGF21 acts in an autocrine/paracrine manner in iBAT and Sc Ing fat depots under cold-acclimating conditions and may contribute to driving depot-specific thermogenic adaptive responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.