ArticleNMR in biomedicine2018
Detecting stress injury (fatigue fracture) in fibular cortical bone using quantitative ultrashort echo time-magnetization transfer (UTE-MT): An ex vivo study.
Article in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
- Quantitative ultrashort echo time (UTE) magnetic resonance imaging of femoral trabecular bone in aging and osteoporosis.European radiology · 2026Article
- Current Landscape of Short-T2 Imaging Techniques in the Musculoskeletal System: The Past, Present and Future.Journal of magnetic resonance imaging : JMRI · 2025Review
- Accelerated ultrashort echo time quantitative magnetization transfer (UTE-qMT) imaging of macromolecular fraction (MMF) in cortical bone based on a self-attention convolutional neural network.Magnetic resonance imaging · 2025Article
- UTE MRI technical developments and applications in osteoporosis: a review.Frontiers in endocrinology · 2025Review
- Are Collagen Protons Visible with the Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequence: A DBioengineering (Basel, Switzerland) · 2024Article
- Significant age-related differences between lower leg muscles of older and younger female subjects detected by ultrashort echo time magnetization transfer modeling.NMR in biomedicine · 2024Article
- Bone Biomarkers Based on Magnetic Resonance Imaging.Seminars in musculoskeletal radiology · 2024Review
- Achilles tendon and enthesis assessment using ultrashort echo time magnetic resonance imaging (UTE-MRI) T1 and magnetization transfer (MT) modeling in psoriatic arthritis.NMR in biomedicine · 2024Article
- Bilateral Stress Fractures of Amputated Tibial Stumps in the Setting of Chronic Compartment Syndrome.Orthopedic research and reviews · 2024Article
- Robust Assessment of Macromolecular Fraction (MMF) in Muscle with Differing Fat Fraction Using Ultrashort Echo Time (UTE) Magnetization Transfer Modeling with Measured T1.Diagnostics (Basel, Switzerland) · 2023Article
- Making the invisible visible-ultrashort echo time magnetic resonance imaging: Technical developments and applications.Applied physics reviews · 2022Review
- Zero-TE MRI: principles and applications in the head and neck.The British journal of radiology · 2022Review
- Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging.Journal of magnetic resonance imaging : JMRI · 2022Review
- Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?Bone reports · 2022Article
- Lower Macromolecular Content in Tendons of Female Patients with Osteoporosis versus Patients with Osteopenia Detected by Ultrashort Echo Time (UTE) MRI.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- Bone Stress Evaluation with and without Cortical Bone Using Several Dental Restorative Materials Subjected to Impact Load: A Fully 3D Transient Finite-Element Study.Materials (Basel, Switzerland) · 2021Article
- Fast field echo resembling a CT using restricted echo-spacing (FRACTURE): a novel MRI technique with superior bone contrast.Skeletal radiology · 2021Article
- Ultrashort echo time adiabatic TMagnetic resonance imaging · 2021Article
- Assessment of mechanical properties of articular cartilage with quantitative three-dimensional ultrashort echo time (UTE) cones magnetic resonance imaging.Journal of biomechanics · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Bone stress injury (BSI) incidents have been increasing amongst athletes in recent years as a result of more intense sporting activities. Cortical bone in the tibia and fibula is one of the most common BSI sites. Nowadays, clinical magnetic resonance imaging (MRI) is the recommended technique for BSI diagnosis at an early stage. However, clinical MRI focuses on edema observations in surrounding soft tissues, rather than the injured components of the bone. Specifically, both normal and injured bone are invisible in conventional clinical MRI. In contrast, ultrashort echo time (UTE)-MRI is able to detect the rapidly decaying signal from the bone. This study aimed to employ UTE-MRI for fatigue fracture detection in fibula cortical bone through an ex vivo investigation. Fourteen human fibular samples (47 ± 20 years old, four women) were subjected to cyclic loading on a four-point bending setup. The loading was displacement controlled to induce -5000 ± 1500 μ-strain at 4 Hz. Loading was stopped when bone stiffness was reduced by 20%. Fibula samples were imaged twice, using UTE-MRI and micro-computed tomography (μCT), first pre-loading and second post-loading. After loading, the macromolecular fraction (MMF) from UTE-MT modeling demonstrated a significant decrease (12% ± 20%, P = 0.02) on average. Single-component T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.