Evidence map›Paper›PMID 30059181›Full record

ReviewThe European journal of neuroscience2020

Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.

Anna N King, Amita Sehgal

Open access · bronzeAbstract readReview
In one paragraph

Review in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 86 citations in OpenAlex.

  1. Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Artificial light at night (ALAN) negatively affects expression of transcripts involved in biosynthesis of molting and juvenile hormones in Bombyx mori.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  3. Review
  4. Article
  5. Clock-related neuropeptides inFrontiers in genetics · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Role of the clock gene homologFrontiers in neuroscience · 2025
    Article
  12. Review
  13. A four-oscillator model of seasonally adapted morning and evening activities in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024
    Review
  14. Article
  15. Review
  16. Tob Regulates the Timing of Sleep Onset at Night inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  17. Article
  18. Dissecting neuron-specific functions of circadian genes using modified cell-specific CRISPR approaches.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anna N KingDepartment of Neuroscience, Perelman School of Medicine, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania.
Amita SehgalDepartment of Neuroscience, Perelman School of Medicine, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-7354-9641
Howard Hughes Medical Institute · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
Interaction between circadian and sleep circuitsR01NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AMITA SEHGAL · 2005 to 2026
$4.8M
Cycling in a circadian circuitR37NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA · 2015 to 2021
$2.7M
Neural mechanisms underlying circadian rhythms in behaviorF31NS100395 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KING, ANNA · 2017 to 2018
$70k
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM008216NINDS NIH HHS F31 NS100395NINDS NIH HHS R01 NS048471NINDS NIH HHS R37 NS048471
6 · The paper itself

Abstract

A central question in the circadian biology field concerns the mechanisms that translate ~24-hr oscillations of the molecular clock into overt rhythms. Drosophila melanogaster is a powerful system that provided the first understanding of how molecular clocks are generated and is now illuminating the neural basis of circadian behavior. The identity of ~150 clock neurons in the Drosophila brain and their roles in shaping circadian rhythms of locomotor activity have been described before. This review summarizes mechanisms that transmit time-of-day signals from the clock, within the clock network as well as downstream of it. We also discuss the identification of functional multisynaptic circuits between clock neurons and output neurons that regulate locomotor activity.

Indexed as

Circadian ClocksDrosophila ProteinsAnimalsBrainCircadian RhythmDrosophilaDrosophila melanogasterDrosophila Proteinscircadian rhythmneuronal activityneuropeptiderest:activity rhythms

Identifiers

PMID30059181
PMCPMC6353709
OpenAlexW2886941307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.