Evidence map›Paper›PMID 30059090›Full record

ArticleChemical communications (Cambridge, England)2018

Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide.

Kortney M Kersten, Meghan E Breen, Anna K Mapp, Adam J Matzger

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. A triclinic polymorph of miconazole.Acta crystallographica. Section E, Crystallographic communications · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Kortney M KerstenDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA. matzger@umich.edu.
Meghan E Breen
Anna K Mapp
Adam J Matzger
University of Michigan · US

Funding

Improving drug bioavailability through solid form discovery SUPPLEMENTR01GM106180 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATZGER, ADAM JAY · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM106180
6 · The paper itself

Abstract

Antimicrobial functionality is introduced into a pharmaceutical formulation of miconazole while improving solubility. The work leverages hydrate formation propensity in order to produce hydrogen peroxide solvates. The ubiquity of hydrate formation suggests that hydrogen peroxide can be broadly deployed in pharmaceuticals, rendering a liquid excipient suitable for solid pharmaceutical formulations.

Indexed as

Anti-Infective AgentsCandida glabrataCrystallizationDrug CompoundingExcipientsHydrogen PeroxideMiconazoleSolubilityAnti-Infective AgentsExcipientsHydrogen PeroxideMiconazole

Identifiers

PMID30059090
PMCPMC6163058
OpenAlexW2883122027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.