ArticleJournal of visualized experiments : JoVE2018
Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography.
Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Hypothalamic Glutamatergic/Orexinergic Neurons Attenuate Fentanyl-Induced Respiratory Depression via Medullary Pre-BöTzinger Complex Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Supplementation of αKG along with TGFβ/HIF1α antagonist rescues lung fibrosis in mice with severe SARS-CoV-2 infection.Journal of translational medicine · 2026Article
- Lung maneuvers of large amplitudes for probing physiological alterations in mouse models of asthma.Animal models and experimental medicine · 2026Article
- Resistive spontaneous breathing exacerbated lipopolysaccharide-induced lung injury in mice.Biochemistry and biophysics reports · 2024Article
- Establishment of a Mouse Model ofMicroorganisms · 2024Article
- Lung function measurements in preclinical research: What has been done and where is it headed?Frontiers in physiology · 2023Review
- Unsupervised classification of plethysmography signals with advanced visual representations.Frontiers in physiology · 2023Article
- A leak-free head-out plethysmography system to accurately assess lung function in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Berberine Alleviates Gastroesophageal Reflux-Induced Airway Hyperresponsiveness in a Transient Receptor Potential A1-Dependent Manner.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Chemistry, lung toxicity and mutagenicity of burn pit smoke-related particulate matter.Particle and fibre toxicology · 2021Article
- Simple low dose radiography allows precise lung volume assessment in mice.Scientific reports · 2021Article
- Smooth Muscle Hypocontractility and Airway Normoresponsiveness in a Mouse Model of Pulmonary Allergic Inflammation.Frontiers in physiology · 2021Article
- Article
- Measuring Breathing Patterns in Mice Using Whole-body Plethysmography.Bio-protocol · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Air volume changes created by a conscious subject breathing spontaneously within a body box are at the basis of plethysmography, a technique used to non-invasively assess some features of the respiratory function in humans as well as in laboratory animals. The present article focuses on the application of the double-chamber plethysmography (DCP) in small animals. It provides background information on the methodology as well as a detailed step-by-step procedure to successfully assess respiratory function in conscious, spontaneously breathing animals in a non-invasive manner. The DCP can be used to monitor the respiratory function of multiple animals in parallel, as well as to identify changes induced by aerosolized substances over a chosen time period and in a repeated manner. Experiments on control and allergic mice are used herein to demonstrate the utility of the technique, explain the associated outcome parameters, as well as to discuss the related advantages and shortcomings. Overall, the DCP provides valid and theoretically sound readouts that can be trusted to evaluate the respiratory function of conscious small animals both at baseline and after challenges with aerosolized substances.
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Registered trials
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