SynthesisJournal of managed care & specialty pharmacy2018
Reasons for Primary Medication Nonadherence: A Systematic Review and Metric Analysis.
Synthesis in Journal of managed care & specialty pharmacy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Initial non-adherence to lipid-lowering medication: a systematic literature review.BMC primary care · 2024Pooled it
- Initial non-adherence to antihypertensive medications in the United States: a systematic literature review.Journal of human hypertension · 2022Pooled it
- Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review.Journal of medical Internet research · 2020Pooled it
- Comparing rates of primary medication nonadherence and turnaround time among patients at a health system specialty pharmacy compared with external specialty pharmacies.Journal of managed care & specialty pharmacy · 2026Article
- Regional Determinants of Non-Adherence: A Quantitative Survey of Healthcare Professionals' Perceptions in Latin America, Asia Pacific, Middle East, Africa, Pakistan and China.Patient preference and adherence · 2026Article
- Impact of structured adherence training on healthcare professionals: a pilot study in Mexico and Thailand.Frontiers in medicine · 2026Article
- Adherence to oral thromboprophylaxis in atrial fibrillation: an overview for clinicians.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- Sentiment analysis in medication adherence: using ruled-based and artificial intelligence-driven algorithms to understand patient medication experiences.International journal of clinical pharmacy · 2025Article
- Examining the cost burden of dietary supplements in older adults: an analysis from the AAA longroad study.BMC geriatrics · 2025Article
- Pharmacoequity measurement framework: A tool to reduce health disparities.Journal of managed care & specialty pharmacy · 2025Article
- Risdiplam utilization, adherence, and associated health care costs for patients with spinal muscular atrophy: a United States retrospective claims database analysis.Orphanet journal of rare diseases · 2024Article
- Treatment patterns and hospitalizations following rejection, reversal, or payment of the initial once-monthly paliperidone palmitate long-acting injectable antipsychotic claim among patients with schizophrenia or schizoaffective disorder.Journal of managed care & specialty pharmacy · 2024Article
- Not obtaining a medication the first time it is prescribed: primary non-adherence to cardiovascular pharmacotherapy.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- Patients' knowledge, attitude, and practices toward unused medications in Qatar: A cross-sectional survey.Heliyon · 2024Article
- Low rates of primary medication nonadherence in patients prescribed oral oncology agents across health system specialty pharmacies.Journal of managed care & specialty pharmacy · 2023Article
- Factors Associated With Asthma Biologic Prescribing and Primary Adherence Among Adults in a Large Health System.The journal of allergy and clinical immunology. In practice · 2023Observational
- A Pilot Study Exploring the Impact of a Primary Medication Non-Adherence Intervention among Four Chronic Disease States in One Regional Division of a Large Community Pharmacy Chain.Pharmacy (Basel, Switzerland) · 2023Article
- Chronic Medication Nonadherence and Potentially Preventable Healthcare Utilization and Spending Among Medicare Patients.Journal of general internal medicine · 2022Article
- COVID-19 vaccination coverage in deprived populations living in segregated colonies: A nationwide cross-sectional study in Hungary.PloS one · 2022Article
- Primary nonadherence to statin medications: Survey of patient perspectives.Preventive medicine reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe behavior of medication nonadherence is distinguished into primary and secondary nonadherence. Primary nonadherence (PNA) is not as thoroughly studied as secondary nonadherence.
objectiveTo explore and synthesize contributing factors to PNA based on the existing body of literature.
methodsA search was performed on the PubMed, PsycINFO, CINAHL, and ScienceDirect databases to identify previously published scholarly articles that described the "factors," "reasons," "determinants" or "facilitators" of PNA. The alternate spelling of "nonadherence" was used as well. The effect that the articles had in the research community, as well as across social media, was also explored.
results22 studies met the inclusion criteria for this review. The PNA factors that the studies identified were diverse, spanning economic, social, and medical dimensions. A multilevel classification method was applied to categorize the factors into 5 broad groups-patient, medication, health care provider, health care system, and socioeconomic factors. Patient factors were reported the most. Some groups overlapped and shared a dynamic causal relationship where one group influenced the outcome of the other.
conclusionsLike all nonadherence behaviors, PNA is multifaceted with highly varied contributing factors that are closely associated with one another. Given the multidimensional nature of PNA, future intervention studies should focus on the dynamic relationship between these factor groups for more efficient outcomes. DISCLOSURES: This research was supported by the National Research Foundation Singapore under its National Innovation Challenge on Active and Confident Ageing (Award No. MOH/NIC/CAHIG03/2016) and administered by the Singapore Ministry of Health's National Medical Research Council. This research was also supported by the National Research Foundation within the Prime Minister's Office of Singapore, under its Science of Research, Innovation and Enterprise Programme (SRIE Award No. NRF2014-NRF-SRIE001-019). The authors have no relevant conflicts of interest to disclose.
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