Evidence map›Paper›PMID 30058722›Full record

ArticleLasers in surgery and medicine2019

1.7 micron optical coherence tomography for vaginal tissue characterization in vivo.

Yan Li, Neha T Sudol, Yusi Miao, Joseph C Jing, Jiang Zhu, Felicia Lane, Zhongping Chen

Registry-linked trialAbstract read
In one paragraph

Article in Lasers in surgery and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06691178 (Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy, a Randomized Controlled Trial), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06691178 narecruitingnot on this mapstarted 2023, after this paper: background citation

Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy, a Randomized Controlled Trial

TypeinterventionalSponsorUniversity of California, IrvineRan2023 to 2027Enrolled50ConditionsGenitourinary Syndrome of MenopauseArmsOptical coherence tomography (OCT)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Imaging theJournal of biomedical optics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. A review of low-cost and portable optical coherence tomography.Progress in biomedical engineering (Bristol, England) · 2021
    Article
  13. Optical Vaginal Biopsy Using Optical Coherence Tomography.Female pelvic medicine & reconstructive surgery · 2020
    Article
  14. Observational
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan LiBeckman Laser Institute, University of California, Irvine, California, 92617.ORCID 0000-0002-3468-9235
Neha T SudolDepartment of Obstetrics & Gynecology, University of California, Irvine, Medical Center, Irvine, California, 92617.
Yusi MiaoBeckman Laser Institute, University of California, Irvine, California, 92617.
Joseph C JingBeckman Laser Institute, University of California, Irvine, California, 92617.
Jiang ZhuBeckman Laser Institute, University of California, Irvine, California, 92617.
Felicia LaneDepartment of Obstetrics & Gynecology, University of California, Irvine, Medical Center, Irvine, California, 92617.
Zhongping ChenBeckman Laser Institute, University of California, Irvine, California, 92617.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2012 to 2017
$7.0M
Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Combined OCT/US/PAT system for intravascular ImagingR01HL127271 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, PATEL, PRANAV · 2015 to 2018
$2.7M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
High Resolution Elastograpy of Retina Under Prosthetic Electrical StimulationR01EY026091 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, ZHOU, QIFA · 2016 to 2019
$2.0M
Elastographic Imaging of the Retina/Choroid in Age-Related Macular DegenerationR01EY021529 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHEN, ZHONGPING, SILVERMAN, RONALD H · 2012 to 2015
$1.4M
National Center for Advancing Translational Sciences UL1 TR001414National Eye Institute R01 EY021529National Eye Institute R01 EY026091National Eye Institute R01 EY028662National Heart, Lung, and Blood Institute R01 HL125084National Heart, Lung, and Blood Institute R01 HL127271National Institute of Biomedical Imaging and Bioengineering P41 EB015890NCATS NIH HHS UL1 TR001414NEI NIH HHS R01 EY021529NEI NIH HHS R01 EY026091NEI NIH HHS R01 EY028662NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01 HL127271NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

objectivesOptical coherence tomography (OCT) can noninvasively visualize in vivo tissue microstructure with high spatial resolution that approaches the histologic level. Currently, OCT studies in gynecology are few and limited to a conventional 1.3 μm center wavelength swept light source which provides high spatial resolution but limited penetration depth. Here, we present a novel endoscopic OCT system with improved penetration depth and high resolution.

methodsA novel endoscopic OCT system was developed based on a 1.7 µm swept source laser, which is capable of deeper tissue penetration due to its longer wavelength. To evaluate the performance of system, we imaged the human vaginas in vivo with both conventional 1.3 and 1.7 μm endoscopic OCT systems.

resultsWith the 1.7 μm endoscopic OCT system, imaging depth was improved by more than 25%, allowing better visualization of the lamina propria and clear contrast of the epithelial layer from the surrounding tissues.

conclusionThe significantly improved performance of the novel 1.7 μm OCT imaging system demonstrates its potential use as a minimally-invasive monitoring tool of vaginal health in gynecologic practice. Lasers Surg. Med. 51:120-126, 2019. © 2018 Wiley Periodicals, Inc.

Indexed as

LasersAdultEndoscopyEquipment DesignFemaleHumansTomography, Optical CoherenceVagina1.7 micron swept-source laserepitheliumgynecologyoptical coherence tomographypenetration depthvagina

Identifiers

PMID30058722
PMCPMC6353703

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.