Evidence map›Paper›PMID 30058598›Full record

ReviewFukushima journal of medical science2018

Immunotherapy for esophageal squamous cell carcinoma: a review.

Kosaku Mimura, Leo Yamada, Daisuke Ujiie, Suguru Hayase, Takeshi Tada, Hiroyuki Hanayama, Aung Kyi Thar Min, Masahiko Shibata, Tomoyuki Momma, Zenichiro Saze and 2 more

Open access · diamondAbstract readReview
In one paragraph

Review in Fukushima journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Kosaku MimuraDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Leo YamadaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Daisuke UjiieDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Suguru HayaseDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Takeshi TadaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Hiroyuki HanayamaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Aung Kyi Thar MinDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Masahiko ShibataDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Tomoyuki MommaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Zenichiro SazeDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Shinji OhkiDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Koji KonoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University.
Fukushima Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer vaccines and immune checkpoint inhibitors (ICI) have recently been employed as immunotherapies for esophageal squamous cell carcinoma (ESCC). Cancer vaccines for ESCC have yielded several promising results from investigator-initiated phase I and II clinical trials. Furthermore, a Randomized Controlled Trial as an adjuvant setting after curative surgery is in progress in Japan. On the other hand, ICI, anti-CTLA-4 mAb and anti-PD-1 mAb, have demonstrated tumor shrinkage and improved overall survival in patients with multiple cancer types. For ESCC, several clinical trials using anti-PD-1/anti-PD-L1 mAb are underway with several recent promising results. In this review, cancer vaccines and ICI are discussed as novel therapeutic strategies for ESCC.

Indexed as

Antibodies, MonoclonalB7-H1 AntigenCancer VaccinesEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaHumansImmunotherapyProgrammed Cell Death 1 ReceptorT-Lymphocytes, CytotoxicAntibodies, MonoclonalB7-H1 AntigenCancer VaccinesProgrammed Cell Death 1 Receptorcancer vaccineesophageal squamous cell carcinomaimmune checkpoint inhibitorsimmunotherapy

Identifiers

PMID30058598
PMCPMC6141453
OpenAlexW2884805237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.