ArticleCancer medicine2018
Preoperative radiation may improve the outcomes of resectable IIIA/N2 non-small-cell lung cancer patients: A propensity score matching-based analysis from surveillance, epidemiology, and end results database.
Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Integrative Approaches in Non-Small Cell Lung Cancer Management: The Role of Radiotherapy.Journal of clinical medicine · 2024Review
- Review
- Lung cancer in middle and southern Morocco.Ecancermedicalscience · 2023Article
- Effect of preoperative radiotherapy on overall survival in N2 non-small-cell lung cancer: a propensity score-matched analysis of Surveillance, Epidemiology, and End Results database.Interactive cardiovascular and thoracic surgery · 2022Article
- Effectiveness of Postoperative or Preoperative Radiotherapy on Prognosis in Patients with Stage II Resectable Non-Small Cell Lung Cancer: A Retrospective Study Based on the SEER Database.Medicina (Kaunas, Lithuania) · 2021Article
- Preoperative and postoperative radiotherapy (RT) for non-small cell lung cancer: still an open question.Translational lung cancer research · 2021Review
- 2020 Innovation-Based Optimism for Lung Cancer Outcomes.The oncologist · 2021Review
- The impact of order with radiation therapy in stage IIIA pathologic N2 NSCLC patients: a population-based study.BMC cancer · 2020Article
- Construction of a nomogram to predict the prognosis of non-small-cell lung cancer with brain metastases.Medicine · 2020Observational
- Causation between Pathway Completion and Reduced Hospital Stay in Patients with Lung Cancer: a Retrospective Cohort Study Using Propensity Score Matching.Journal of medical systems · 2020Article
- Chest wall resection and reconstruction for lung cancer: surgical techniques and example of integrated multimodality approach.Journal of thoracic disease · 2020Article
- A nomogram for the prediction of overall survival in patients with stage II and III non-small cell lung cancer using a population-based study.Oncology letters · 2019Article
- Article
- Patients with Lower Positive Lymph Nodes Ratio May Benefit from Preoperative Radiotherapy in Stage III Non-Small Cell Lung Cancer.Technology in cancer research & treatmentArticle
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5 authors.
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Abstract
backgroundThere are several therapeutic strategies for the management of resectable stage IIIA/N2 non-small-cell lung cancer (NSCLC) patients. However, the role of radiotherapy as a preoperative adjuvant therapy is unclear.
methodsWe retrospectively analyzed the data of stage IIIA/N2 NSCLC patients who either underwent preoperative radiation (PrORT), or did not undergo preoperative radiation, collected from the Surveillance, Epidemiology and End Results (SEER) database, between 2004 and 2013. The primary endpoints were cancer-specific survival (CSS) and overall survival (OS).
resultsUltimately, 493 patients treated with preoperative radiation and 2675 patients treated who were not treated with preoperative radiation, were included in the analysis. Overall, preoperative radiation was associated with a better CSS (HR: 1.427 [1.297-1.572], P = 0.014) and OS (HR: 1.220 [1.131-1.493], P = 0.002) than that observed in patients who did not undergo preoperative radiation. After PSM, preoperative radiation still showed advantage in both CSS and OS. Only age, T stage, and preoperative radiation remained independent prognostic factors for both OS and CSS. In the subgroup analysis, the advantages of preoperative radiotherapy were more pronounced in patients with stage T3 tumors and highly differentiated tumors.
conclusionsPreoperative radiation may improve the outcomes of resectable IIIA/N2 NSCLC patients. In IIIA/N2 NSCLC patients, particularly with T3 and highly differentiated tumors, clinicians should boldly apply preoperative radiotherapy to improve the patients' survival.
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