ArticleThe International journal of eating disorders2018
Exploring reward system responsivity in the nucleus accumbens across chronicity of binge eating in female rats.
Article in The International journal of eating disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Neurobiological Mechanisms and Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Binge Eating Disorder: A Narrative Review.International journal of molecular sciences · 2025Review
- Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell.Neuroscience bulletin · 2024Article
- Integrating aspects of affect, reward, and cognition to develop more comprehensive models of binge-eating pathology.The International journal of eating disorders · 2023Review
- Examination of onset trajectories and persistence of binge-like eating behavior in mice after intermittent palatable food exposure.Behavioral neuroscience · 2023Article
- A literature review of dopamine in binge eating.Journal of eating disorders · 2022Review
- Breaking It Down: Investigation of Binge Eating Components in Animal Models to Enhance Translation.Frontiers in psychiatry · 2021Review
- The Disruptive Effects of Estrogen Removal before Puberty on Risk for Binge Eating in Female Rats.Clinical psychological science : a journal of the Association for Psychological Science · 2020Article
- A virtual issue highlighting animal studies of eating disorders as valuable tools for examining neurobiological underpinnings and treatment of eating disorders.The International journal of eating disorders · 2020Article
- Reduced sensitivity to devaluation for instrumental but not consummatory behaviors in binge eating prone rats.Physiology & behavior · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
objectiveResearch has highlighted the importance of reward-based processes in binge eating (BE). However, both increased and decreased activation have been observed in reward related brain regions for BE. Differences may be similar to addiction research, where the reward system is initially hyper-responsive at early stages of use, but becomes hypo-responsive with prolonged drug/alcohol use. This study was the first to examine differences in reward system responsivity at early versus chronic BE stages.
methodUsing an animal model, Sprague-Dawley female rats were identified as BE prone (BEP) or BE resistant (BER) and randomly assigned to an early or chronic stage group. Neural activation (via Fos protein) was quantified in the nucleus accumbens core (NAC) and shell (NAS).
resultsEarly stage BEP rats had the highest levels of Fos expression of all of the study groups. By contrast, chronic stage BEP rats exhibited decreased activation in the NAS and NAC that was similar to the activation in chronic stage BER rats. DISCUSSION: Findings are significant in suggesting hyper-neural activation to reward in the early stages of BE and decreased activation in later stages of BE. Additional studies are needed to elucidate how these differences may impact risk for and maintenance of BE.
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