ArticleJournal of tissue engineering and regenerative medicine2018
Rabbit xenogeneic transplantation model for evaluating human chondrocyte sheets used in articular cartilage repair.
Article in Journal of tissue engineering and regenerative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Meniscal engraftment of iPSC-derived cartilage particles as hyaline and fibrous cartilage in a rabbit injury model.Regenerative therapy · 2026Article
- A New Way to Engineer Cell Sheets for Articular Cartilage Regeneration.Journal of functional biomaterials · 2025Article
- Long-term immunosuppression of rabbits through oral tacrolimus administration.Animal models and experimental medicine · 2025Article
- Regenerative Variability of Human Juvenile Chondrocyte Sheets From Different Cell Donors in an Athymic Rat Knee Chondral Defect Model.Cartilage · 2024Article
- Tailoring cell sheets for biomedical applications.Smart medicine · 2024Review
- Cell Therapy Approaches for Articular Cartilage Regeneration.Organogenesis · 2023Review
- A novel chondrocyte sheet fabrication using human-induced pluripotent stem cell-derived expandable limb-bud mesenchymal cells.Stem cell research & therapy · 2023Article
- Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis.NPJ Regenerative medicine · 2022Article
- 3D Printing for Bone-Cartilage Interface Regeneration.Frontiers in bioengineering and biotechnology · 2022Review
- Development of Injectable Polydactyly-Derived Chondrocyte Sheets.International journal of molecular sciences · 2021Article
- Review
- Potential of Exosomes for Diagnosis and Treatment of Joint Disease: Towards a Point-of-Care Therapy for Osteoarthritis of the Knee.International journal of molecular sciences · 2021Review
- Novel therapies using cell sheets engineered from allogeneic mesenchymal stem/stromal cells.Emerging topics in life sciences · 2020Review
- Fabrication of hyaline-like cartilage constructs using mesenchymal stem cell sheets.Scientific reports · 2020Article
- Regenerative effects of human chondrocyte sheets in a xenogeneic transplantation model using immune-deficient rats.Journal of tissue engineering and regenerative medicine · 2020Article
- Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration.International journal of molecular sciences · 2019Article
- Rabbit xenogeneic transplantation model for evaluating human chondrocyte sheets used in articular cartilage repair.Journal of tissue engineering and regenerative medicine · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Research on cartilage regeneration has developed novel sources for human chondrocytes and new regenerative therapies, but appropriate animal models for translational research are needed. Although rabbit models are frequently used in such studies, the availability of immunocompromised rabbits is limited. Here, we investigated the usefulness of an immunosuppressed rabbit model to evaluate directly the efficacy of human chondrocyte sheets through xenogeneic transplantation. Human chondrocyte sheets were transplanted into knee osteochondral defects in Japanese white rabbits administered with immunosuppressant tacrolimus at a dosage of 0.8 or 1.6 mg/kg/day for 4 weeks. Histological evaluation at 4 weeks after transplantation in rabbits administered 1.6 mg/kg/day showed successful engraftment of human chondrocytes and cartilage regeneration involving a mixture of hyaline cartilage and fibrocartilage. No human chondrocytes were detected in rabbits administered 0.8 mg/kg/day, although regeneration of hyaline cartilage was confirmed. Histological evaluation at 12 weeks after transplantation (i.e., 8 weeks after termination of immunosuppression) showed strong immune rejection of human chondrocytes, which indicated that, even after engraftment, articular cartilage is not particularly immune privileged in xenogeneic transplantation. Our results suggest that Japanese white rabbits administered tacrolimus at 1.6 mg/kg/day and evaluated at 4 weeks may be useful as a preclinical model for the direct evaluation of human cell-based therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.