ArticleMagnetic resonance in medicine2019
Toward more reliable measurements of NOE effects in CEST spectra at around -1.6 ppm (NOE (-1.6)) in rat brain.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Multimodal MRI Reveals Cerebral and Vascular Amyloid-Driven Myeloarchitectural Disorganization in a Mouse Model of Alzheimer's Disease.NMR in biomedicine · 2026Article
- Interpreting amide proton transfer-weighted imaging contrast between normal and tumor brain tissues using the asymmetry analysis method at 4.7 T.Magnetic resonance in medicine · 2026Article
- Double-Step R1rho-Based Lorentzian Fitting (DROF): A New CEST Analysis Approach and Its Comparison With Existing Methods.NMR in biomedicine · 2025Article
- Specific and rapid guanidinium CEST imaging using double saturation power and QUASS analysis in a rodent model of global ischemia.Magnetic resonance in medicine · 2024Article
- Nuclear Overhauser enhancement imaging at -1.6 ppm in rat brain at 4.7T.Magnetic resonance in medicine · 2024Article
- Estimating the synaptic density deficit in Alzheimer's disease using multi-contrast CEST imaging.PloS one · 2024Article
- Investigation of relayed nuclear Overhauser enhancement effect at -1.6 ppm in an ischemic stroke model.Quantitative imaging in medicine and surgery · 2023Article
- Comparison of model-free Lorentzian and spinlock model-based fittings in quantitative CEST imaging of acute stroke.Magnetic resonance in medicine · 2023Article
- Validation of the presence of fast exchanging amine CEST effect at low saturation powers and its influence on the quantification of APT.Magnetic resonance in medicine · 2023Article
- Evaluation of contributors to amide proton transfer-weighted imaging and nuclear Overhauser enhancement-weighted imaging contrast in tumors at a high magnetic field.Magnetic resonance in medicine · 2023Article
- Assignment of molecular origins of NOE signal at -3.5 ppm in the brain.Magnetic resonance in medicine · 2023Article
- In vivo reproducibility of 3D relayed NOE in the healthy human brain at 7 T.Magnetic resonance in medicine · 2023Article
- Noninvasively differentiating acute and chronic nephropathies via multiparametric urea-CEST, nuclear Overhauser enhancement-CEST, and quantitative magnetization transfer MRI.Magnetic resonance in medicine · 2023Article
- NOE-weighted imaging in tumors using low-duty-cycle 2π-CEST.Magnetic resonance in medicine · 2023Article
- Quasi-steady-state amide proton transfer (QUASS APT) MRI enhances pH-weighted imaging of acute stroke.Magnetic resonance in medicine · 2022Article
- Chemical Exchange Saturation Transfer (CEST) Signal at -1.6 ppm and Its Application for Imaging a C6 Glioma Model.Biomedicines · 2022Article
- Contribution of blood to nuclear Overhauser effect at -1.6 ppm.Magnetic resonance in medicine · 2022Article
- Delayed urea differential enhancement CEST (dudeCEST)-MRI with TMagnetic resonance in medicine · 2021Article
- CEST MRI quantification procedures for breast cancer treatment-related lymphedema therapy evaluation.Magnetic resonance in medicine · 2020Article
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Abstract
purposeRecently, a new relayed nuclear Overhauser enhancement (NOE) saturation transfer effect at around -1.6 parts per million, termed NOE(-1.6), and its potential applications in tumor and stroke were reported by several institutes. However, there is a concern of the reproducibility of NOE(-1.6) measurements because it is not reported by many other publications. This paper aims to study the influence of typically overlooked experimental settings on the NOE(-1.6) signal and to build a framework for more reliable measurements of NOE(-1.6) at 9.4T.
methodsZ-spectra were obtained in rat brains. A fitting approach was performed to quantify all known saturation transfer effects except NOE(-1.6). Residual signals were obtained by removing these confounding effects from Z-spectra and were then used to quantify NOE(-1.6). Multislice imaging was performed to study the NOE(-1.6) dependence on brain regions. The influences of euthanasia, anesthesia, breathing gases, and RF irradiation power were also evaluated.
resultsResults demonstrate that the NOE(-1.6) signal contributions are often not clearly observable in raw Z-spectra at relatively high irradiation powers due to, for example, the direct water saturation effect, but they can be visualized after removing other nonspecific effects. In addition, the NOE(-1.6) effect depends on brain region, decreases postmortem, shifts after long-duration anesthesia, and may be enhanced by increasing O
conclusionBecause the NOE(-1.6) effect is more susceptible to the direct water saturation effect and more sensitive to physiological conditions than are other CEST effects, incorporating known sensitivities into the experimental design and data analysis is necessary to ensure more reliable NOE(-1.6) results.
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