Evidence map›Paper›PMID 30058056›Full record

SynthesisJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2018

Outcomes of ICDs and CRTs in patients with chronic kidney disease: a meta-analysis of 21,000 patients.

Mohammed Shurrab, Dennis T Ko, Yazan Zayed, Sankar D Navaneethan, Nour Yadak, Abeer Yaseen, Anna Kaoutskaia, Waad Qamhia, Zakaria Hamdan, Saleem Haj-Yahia and 5 more

Open access · greenAbstract readComparative StudyMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Impact of underlying kidney disease on the outcomes of cardiac implantable electronic devices in patients with heart failure.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  2. Clinical phenotypes and outcomes associated with improved left ventricular ejection fraction after biventricular pacing.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 5 countries.

Mohammed ShurrabCardiology Department, Health Sciences North, Sudbury, Ontario, Canada. shurrabm@hotmail.com.
Dennis T KoInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Yazan ZayedDepartment of Medicine, Hurley Medical Center, Flint, MI, USA.
Sankar D NavaneethanSelzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Nour YadakCardiology Department, An-Najah National University Hospital, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Abeer YaseenCardiology Department, An-Najah National University Hospital, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Anna KaoutskaiaDivision of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Waad QamhiaCardiology Department, An-Najah National University Hospital, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Zakaria HamdanCardiology Department, An-Najah National University Hospital, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Saleem Haj-YahiaCardiology Department, An-Najah National University Hospital, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Douglas S LeeInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
David NewmanDivision of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Jeff S HealeyPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Paula HarveyDivision of Cardiology, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
Eugene CrystalDivision of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
National University Hospital · SGAn-Najah National University · PSHealth Sciences Centre · CAUniversity of Toronto · CABaylor College of Medicine · USHurley Medical Center · USMcMaster University · CANOSM University · CAUniversity Health Network · CAWomen's College Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe efficacy of implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) in patients with chronic kidney disease (CKD) remains unclear. The aim of this meta-analysis is to explore the association between ICD/CRT and mortality in CKD patients.

methodsAn electronic search was conducted using MEDLINE. We included studies that reported outcomes of interest in CKD patients stratified by the presence of ICD, CRT, or none. The primary outcome was all-cause mortality. Outcomes were pooled using random effects model. Odds ratios (OR) were reported for dichotomous variables.

resultsThe literature search resulted in 11 studies (observational studies) including 21,136 adult patients: seven studies compared ICD vs. no ICD and four studies compared CRT vs. ICD. All-cause mortality was significantly lower in the ICD group in comparison to that in the no ICD group (OR 0.66 (95% confidence interval [CI] 0.45; 0.98), P = 0.04). Among dialysis-only patients, all-cause mortality was significantly lower in the ICD group (OR 0.49 (95% CI 0.38; 0.64), P < 0.001). All-cause mortality was significantly lower in the CRT group in comparison to that in the ICD group (OR 0.73 (95% CI 0.57; 0.92), P = 0.01).

conclusionsThe use of ICDs is associated with lower all-cause mortality in observational studies of CKD patients. CRT use was also associated with lower all-cause mortality in CKD patients in comparison to ICDs. A randomized controlled trial is required to definitively define the role of ICDs/CRTs in CKD patients.

Indexed as

Cardiac Resynchronization TherapyDefibrillators, ImplantableCause of DeathCohort StudiesFemaleHeart FailureHumansMaleObservational Studies as TopicPrognosisRenal DialysisRenal Insufficiency, ChronicRetrospective StudiesSurvival AnalysisTreatment OutcomeChronic kidney diseaseCRTICDMortality

Identifiers

PMID30058056
OpenAlexW2886214692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.