ArticlemSystems
Responses of the Human Gut
Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Risk Factors Associated with Shiga-toxinInternational journal of veterinary science and medicine · 2026Article
- Shiga Toxin-ProducingMicroorganisms · 2025Review
- Hammerhead ribozymes directed against mRNA of an essential gene inhibitFrontiers in microbiology · 2025Article
- Viroid-like colonists of human microbiomes.Cell · 2024Article
- Foodborne bacteria in milk and milk products along the water buffalo milk chain in Bangladesh.Scientific reports · 2024Article
- Rapid turnover and short-term blooms ofJournal of bacteriology · 2024Article
- Viroid-like colonists of human microbiomes.bioRxiv : the preprint server for biology · 2024Article
- Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping.International journal of molecular sciences · 2023Review
- Genomic diversity of non-diarrheagenic fecal Escherichia coli from children in sub-Saharan Africa and south Asia and their relatedness to diarrheagenic E. coli.Nature communications · 2023Article
- Article
- Strong pathogen competition in neonatal gut colonisation.Nature communications · 2022Article
- A longitudinal study of dominant E. coli lineages and antimicrobial resistance in the gut of children living in an upper middle-income country.Journal of global antimicrobial resistance · 2022Article
- The microbial ecology of Escherichia coli in the vertebrate gut.FEMS microbiology reviews · 2022Review
- Pathogenomes and variations in Shiga toxin production among geographically distinct clones ofMicrobial genomics · 2022Article
- Murine Model for Measuring Effects of Humanized-Dosing of Antibiotics on the Gut Microbiome.Frontiers in microbiology · 2022Article
- Environmental Spread of Extended Spectrum Beta-Lactamase (ESBL) ProducingEnvironmental health perspectives · 2021Article
- Article
- Aspartame, acesulfame K and sucralose- influence on the metabolism ofMetabolism open · 2020Article
- Review
- Factors Obscuring the Role ofInternational journal of environmental research and public health · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Studies of Escherichia coli in the human gastrointestinal tract have focused on pathogens, such as diarrhea-causing enterotoxigenic E. coli (ETEC), while overlooking the resident, nonpathogenic E. coli community. Relatively few genomes of nonpathogenic E. coli strains are available for comparative genomic analysis, and the ecology of these strains is poorly understood. This study examined the diversity and dynamics of resident human gastrointestinal E. coli communities in the face of the ecological challenges presented by pathogen (ETEC) challenge, as well as of antibiotic treatment. Whole-genome sequences obtained from E. coli isolates from before, during, and after ETEC challenge were used in phylogenomic and comparative genomic analyses to examine the diversity of the resident E. coli communities, as well as the dynamics of the challenge strain, H10407, a well-studied ETEC strain (serotype O78:H11) that produces both heat-labile and heat-stable enterotoxins. ETEC failed to become the dominant E. coli clone in two of the six challenge subjects, each of whom exhibited limited or no clinical presentation of diarrhea. The E. coli communities of the remaining four subjects became ETEC dominant during the challenge but reverted to their original, subject-specific populations following antibiotic treatment, suggesting resiliency of the resident E. coli population following major ecological disruptions. This resiliency is likely due in part to the abundance of antibiotic-resistant ST131 E. coli strains in the resident populations. This report provides valuable insights into the potential interactions of members of the gastrointestinal microbiome and its responses to challenge by an external pathogen and by antibiotic exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.