Evidence map›Paper›PMID 30057935›Full record

ArticleTechnology2018

Automated end-to-end blood testing at the point-of-care: Integration of robotic phlebotomy with downstream sample processing.

M L Balter, J M Leipheimer, A I Chen, A Shrirao, T J Maguire, M L Yarmush

Abstract read
In one paragraph

Article in Technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  7. Anemia in salmon aquaculture: Scotland as a case study.Aquaculture (Amsterdam, Netherlands) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M L BalterDepartment of Biomedical Engineering, Rutgers University, Piscataway NJ 08854, USA.
J M LeipheimerDepartment of Biomedical Engineering, Rutgers University, Piscataway NJ 08854, USA.
A I ChenDepartment of Biomedical Engineering, Rutgers University, Piscataway NJ 08854, USA.
A ShriraoDepartment of Biomedical Engineering, Rutgers University, Piscataway NJ 08854, USA.
T J MaguireDepartment of Biomedical Engineering, Rutgers University, Piscataway NJ 08854, USA.
M L YarmushDepartment of Biomedical Engineering, Rutgers University, Piscataway NJ 08854, USA.
Rutgers, The State University of New Jersey · US

Funding

UMDNJ TRAINING GRANT IN BIOTECHNOLOGYT32GM008339 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI YARMUSH, MARTIN L · 1989 to 2019
$6.1M
Portable automated device for rapid venous blood draws and point of care diagnostic analysisR01EB020036 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI YARMUSH, MARTIN L · 2015 to 2018
$2.7M
Low-Cost, Compact, and Portable Robot for Autonomous Intravenous Access using NeaF31EB018191 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI CHEN, ALVIN · 2014 to 2015
$67k
NIBIB NIH HHS F31 EB018191NIBIB NIH HHS R01 EB020036NIGMS NIH HHS T32 GM008339
6 · The paper itself

Abstract

Diagnostic blood testing is the most commonly performed clinical procedure in the world, and influences the majority of medical decisions made in hospital and laboratory settings. However, manual blood draw success rates are dependent on clinician skill and patient physiology, and results are generated almost exclusively in centralized labs from large-volume samples using labor-intensive analytical techniques. This paper presents a medical device that enables end-to-end blood testing by performing blood draws and providing diagnostic results in a fully automated fashion at the point-of-care. The system couples an image-guided venipuncture robot, developed to address the challenges of routine venous access, with a centrifuge-based blood analyzer to obtain quantitative measurements of hematology. We first demonstrate a white blood cell assay on the analyzer, using a blood mimicking fluid spiked with fluorescent microbeads, where the area of the packed bead layer is correlated with the bead concentration. Next we perform experiments to evaluate the pumping efficiency of the sample handling module. Finally, studies are conducted on the integrated device - from blood draw to analysis - using blood vessel phantoms to assess the accuracy and repeatability of the resulting white blood cell assay.

Indexed as

Centrifugal MicrofluidicsMedical RoboticsMicroscale Sample ProcessingPoint-of-Care Blood TestingVenous Access

Identifiers

PMID30057935
PMCPMC6058193
OpenAlexW2806818597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.