ArticleJournal of diabetes research2018
Impact of Metabolic Syndrome Factors on Testosterone and SHBG in Type 2 Diabetes Mellitus and Metabolic Syndrome.
Article in Journal of diabetes research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Distinct patterns of hypogonadism in a cross-sectional study of Malaysian men with type 2 diabetes mellitus: The role of insulin resistance, visceral adiposity, and aging.Journal of diabetes investigation · 2025Article
- Association of age and insulin resistance with sex hormone-binding globulin levels in healthy men.Archives of endocrinology and metabolism · 2025Article
- Gonadal hormones and metabolic syndrome in middle-aged and elderly males: results from a prospective cohort study in China.Frontiers in endocrinology · 2024Article
- Gaps in the management of diabetes in Asia: A need for improved awareness and strategies in men's sexual health.Journal of diabetes investigation · 2022Review
- Impact of triglycerides and waist circumference on insulin resistance and β-cell function in non-diabetic first-degree relatives of type 2 diabetes.BMC endocrine disorders · 2021Article
- Aquatic Exercise Positively Affects Physiological Frailty among Postmenopausal Women: A Randomized Controlled Clinical Trial.Healthcare (Basel, Switzerland) · 2021Article
- SHBG levels in primary infertile men: a critical interpretation in clinical practice.Endocrine connections · 2020Article
- The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts.Sexual medicine · 2020Review
- Androgen-Regulated Cardiac Metabolism in Aging Men.Frontiers in endocrinology · 2020Review
- Men with Latent Autoimmune Diabetes and Type 2 Diabetes May Have Different Change Patterns in Free Testosterone.BioMed research international · 2020Observational
- Endogenous SHBG levels correlate with that of glucose transporters in insulin resistance model cells.Molecular biology reports · 2019Article
- Can Low SHBG Serum Concentration Be A Good Early Marker Of Male Hypogonadism In Metabolic Syndrome?Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Assessment of Hypogonadism and Erectile Dysfunction in Males with Prediabetes: A Cross-Sectional Study from North India.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSeveral studies have often reported low testosterone and SHBG to be associated with type 2 DM and the metabolic syndrome (MetS). Our objective was to determine the impact of metabolic syndrome and diabetic parameters on testosterone and SHBG in both MetS subjects and type 2 DM patients.
methodsIn this study, 120 Yemeni male aged 30-70 years old were enrolled, 30 of whom were healthy subjects with BMI < 25 kg/m
resultsTestosterone (free and total) and SHBG were significantly lower in MetS subjects and modestly reduced in type 2 DM with and without MetS. Stepwise linear regression showed free and total testosterone to be negatively affected by waist circumference, and univariate analysis shows this significant difference to disappear when adjusted for waist circumference. On the other hand, stepwise linear regression showed SHBG to be positively affected by testosterone and age and negatively affected by FBG and TG. Univariate analysis shows this observed significant difference to disappear when adjusted for testosterone.
conclusionAbdominal obesity is a major determinant of low testosterone levels irrespective of diabetes status. Thus, supporting evidence suggesting that the causative relationship between the often low testosterone and type 2 DM might be bidirectional or even multidirectional and interrelated with obesity, MetS, and IR.
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