Trial reportBioMed research international2018
A Comparative
Trial report in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Comparing the Effectiveness of Platelet-Rich Plasma Alone Versus Combined With Microneedles or Radiofrequency for Neck Wrinkle Treatment.Journal of cosmetic dermatology · 2025Trial
- Muscles as Basic Therapeutic Units in Glabellar Botulinum Toxin Injection: Technique Description and Preliminary Clinical Experience.Aesthetic plastic surgery · 2026Article
- A dual track predictive model for assessing crow's feet aging across different clinical severity grades.Scientific reports · 2026Article
- The Neuromuscular Junction Distribution in the Upper Face: An Anatomy-to-Practice Review to Inform Botulinum Toxin Type A Treatment Planning.Journal of cosmetic dermatology · 2026Review
- Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NADStem cell research & therapy · 2025Article
- Microneedle for Botulinum Toxin: A Randomized, Case-control, Single-blind Study to Assess Clinical Efficacy and Patient Satisfaction.Plastic and reconstructive surgery. Global open · 2025Article
- Efficacy and Safety of Needle-Free Microjet Injection Versus Needle Injection of Botulinum Toxin for the Treatment of Crow's Feet: A Randomized Split-Face Pilot Study.Annals of dermatology · 2024Article
- A new Chinese crow's feet grading scale based on the DermaTOP system.Scientific reports · 2023Article
- Successful Topical Application of Botulinum Toxin After Microneedling Versus Microneedling Alone for the Treatment of Atrophic Post Acne Scars: A Prospective, Split-face, Controlled Study.The Journal of clinical and aesthetic dermatology · 2022Article
- The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging: AnBioactive materials · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the efficacy and safety of three treatment approaches to applying Botulinum Toxin Type A (BoNTA) for crow's Feet.
methodsThirty female subjects with moderate-to-severe crow's feet were included in this comparative
resultsFor dynamic wrinkles, intramuscular injection and intradermal microdroplets injection were more effective than nanomicroneedles. For static wrinkles, nanomicroneedles and intradermal microdroplets injection were more effective. However, the intramuscular injection had no significant effect on static wrinkles. At one week and four weeks after the treatment, the skin elasticity, collagen content, and hydration of nanomicroneedle group and intradermal microdroplet group increased more significantly than those of the intramuscular injection group; at twelve weeks after the treatment, the skin elasticity, collagen content, and hydration of intradermal microdroplet group were higher than those of other two groups. However we observed no statistically significant difference in sebum content between the three groups before and after the treatment.
conclusionBoNTA delivered through nanomicroneedles and intradermal microdroplets injection can effectively treat crow's feet. This trial is registered with [2016]KY018-01, registered 16 Feb 2016.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.