Evidence map›Paper›PMID 30057689›Full record

ArticleAnnual review of condensed matter physics2018

Adaptation of Living Systems.

Yuhai Tu, Wouter-Jan Rappel

Open access · bronzeAbstract read
In one paragraph

Article in Annual review of condensed matter physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Living Hydrogels: Harnessing Microorganism-Material Synergy for Next-Generation Therapeutics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Stochastic thermodynamics for biological functions.Quantitative biology (Beijing, China) · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Eukaryotic gene regulation at equilibrium, or non?Current opinion in systems biology · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yuhai TuIBM T. J. Watson Research Center, Yorktown Heights, NY 10598.
Wouter-Jan RappelDepartment of Physics, UCSD, La Jolla, CA 92093.
University of California, San Diego · US

Funding

Project 5P01GM078586 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAPPEL, WOUTER-JAN · 2007 to 2016
$11.2M
Quantitative Modeling of Signal Transduction in Bacterial ChemotaxisR01GM081747 · NIGMS · IBM THOMAS J. WATSON RESEARCH CENTER · PI TU, YUHAI · 2007 to 2018
$2.6M
NIGMS NIH HHS P01 GM078586NIGMS NIH HHS R01 GM081747
6 · The paper itself

Abstract

Adaptation refers to the biological phenomenon where living systems change their internal states in response to changes in their environments in order to maintain certain key functions critical for their survival and fitness. Adaptation is one of the most ubiquitous and arguably one of the most fundamental properties of living systems. It occurs throughout all biological scales, from adaptation of populations of species over evolutionary time to adaptation of a single cell to different environmental stresses during its life span. In this article, we review some of the recent progress made in understanding molecular mechanisms of cellular level adaptation. We take the minimalist (or the physicist) approach and study the simplest systems that exhibit generic adaptive behaviors. We focus on understanding the basic biochemical interaction networks in living matter that are responsible for adaptation dynamics. By combining theoretical modeling with quantitative experimentation, we demonstrate universal features in adaptation as well as important differences in different cellular systems, including chemotaxis in bacterium cells (

Indexed as

AdaptationBiochemical NetworkChemotaxisDynamicsGradient SensingModelingMolecular MechanismNonequilibrium

Identifiers

PMID30057689
PMCPMC6060625
OpenAlexW2774136235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.