Evidence map›Paper›PMID 30057678›Full record

ArticleOxidative medicine and cellular longevity2018

Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects.

Kateřina Vaňková, Ivana Marková, Jana Jašprová, Aleš Dvořák, Iva Subhanová, Jaroslav Zelenka, Iva Novosádová, Jan Rasl, Tomáš Vomastek, Roman Sobotka and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Bilirubin: translational perspectives.Pediatric research · 2026
    Review
  3. Coastal halophyte plantRSC advances · 2025
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  7. Article
  8. Carbon Monoxide-Releasing Activity of Plant Flavonoids.Journal of agricultural and food chemistry · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Lipophilic and Hydrophilic Compounds fromLife (Basel, Switzerland) · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kateřina VaňkováInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Ivana MarkováInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Jana JašprováInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Aleš DvořákInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID 0000-0002-1285-6928
Iva SubhanováInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Jaroslav ZelenkaDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague, Czech Republic.
Iva NovosádováInstitute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Jan RaslInstitute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Tomáš VomastekInstitute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Roman SobotkaInstitute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Lucie MuchováInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID 0000-0003-2082-1060
Libor VítekInstitute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID 0000-0002-5318-0151
Charles University · CZCzech Academy of Sciences · CZUniversity of Chemistry and Technology, Prague · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nutritional factors which exhibit antioxidant properties, such as those contained in green plants, may be protective against cancer. Chlorophyll and other tetrapyrrolic compounds which are structurally related to heme and bilirubin (a bile pigment with antioxidant activity) are among those molecules which are purportedly responsible for these effects. Therefore, the aim of our study was to assess both the antiproliferative and antioxidative effects of chlorophylls (chlorophyll

Indexed as

Antineoplastic AgentsAntioxidantsCell Line, TumorCell SurvivalChlorophyllExtracellular Signal-Regulated MAP KinasesGlutathioneGlutathione DisulfideHeme Oxygenase (Decyclizing)HumansHydrogen PeroxideMitochondriaOxidation-ReductionPancreatic NeoplasmsPheophytinsReal-Time Polymerase Chain ReactionAntineoplastic AgentsAntioxidantsChlorophyllExtracellular Signal-Regulated MAP KinasesGlutathioneGlutathione DisulfideHeme Oxygenase (Decyclizing)Hydrogen Peroxidepheophytin aPheophytinsSuperoxides

Identifiers

PMID30057678
PMCPMC6051000
OpenAlexW2811491324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.