ArticleEvidence-based complementary and alternative medicine : eCAM2018
Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Methanolic extract of Ephedra ciliata promotes wound healing and arrests inflammatory cascade in vivo through downregulation of TNF-α.Inflammopharmacology · 2020Pooled it
- Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing.Journal of nanobiotechnology · 2024Review
- Evaluation of Wound Healing Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root ofJournal of experimental pharmacology · 2024Article
- The wound healing effect of botanicals and pure natural substances used in in vivo models.Inflammopharmacology · 2023Review
- Evaluation of Wound Healing Activity of 80% Methanol Stem-Bark Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Wound Healing and Antioxidant Properties of 80% Methanol Leaf Extract ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Antibacterial and Antifungal Activities of Ethiopian Medicinal Plants: A Systematic Review.Frontiers in pharmacology · 2021Article
- Antihyperglycemic Activity of TLC Isolates from the Leaves ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Wound Healing Activities of Hydromethanolic Crude Extract and Solvent Fractions ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Investigation of Wound Healing and Anti-Inflammatory Activities of Leaf Gel ofJournal of inflammation research · 2021Article
- Evaluation of Antidiabetic Effect of Ethanolic Leaves Extract ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- In Vivo Evaluation of Wound Healing and Anti-Inflammatory Activity of 80% Methanol Crude Flower Extract ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Antibacterial and Antifungal Activities of the Leaf Exudate ofInternational journal of microbiology · 2020Article
- Antimicrobial Evaluation of Latex and TLC Fractions from the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- A novel self-nanoemulsifying drug delivery system for curcumin used in the treatment of wound healing and inflammation.3 Biotech · 2019Article
- In vitro α-amylase inhibitory effect of TLC isolates of Aloe megalacantha baker and Aloe monticola Reynolds.BMC complementary and alternative medicine · 2019Article
- Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates fromEvidence-based complementary and alternative medicine : eCAM · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPURPOSE: The aim of this study was to evaluate
methodsThe wound healing activity of the leaf latex of the plant was studied topically by incorporating the latex in simple ointment base in a concentration of 5% (w/w) and 10% (w/w) using excision and incision models. In these models, wound contraction, period of epithelialization, and breaking strength of the wounded skin were determined. Carrageenan induced inflammation of paw model was also used to assess the anti-inflammatory activity of the leaf latex at doses of 200 mg/kg, 400mg/kg, and 600 mg/kg. The level of inflammation suppressions were measured at 1, 2, 3, and 4 hrs after carrageenan injection, and then the percentages of inflammation inhibition were computed as compared with the negative control.
resultIn both wound models, mice treated with 5% (w/w) and 10% (w/w) latex ointment showed a significant (p<0.05) increment in the rate of wound contraction, reduction in epithelialization time, and higher skin breaking strength. Besides, the latex also exhibited a dose-dependent significant (p<0.05) reductions of inflammation as compared to negative control groups.
conclusionThe overall results of this study demonstrate that the leaf latex of
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.