ReviewJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2018
Is aluminum exposure a risk factor for neurological disorders?
Review in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Beyond the Mind-Serum Trace Element Levels in Schizophrenic Patients: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- High prevalence of kaolin consumption in migrant women living in a major urban area of France: A cross-sectional investigation.PloS one · 2019Trial
- Article
- Characterizing the molecular mechanisms underlying aluminium-induced disruptions in neuronal survival pathways.Metabolic brain disease · 2026Review
- Kaempferol-Conjugated Manganese Oxide Nanocomposites Mitigate Aluminium Chloride-Induced Neurobehavioral Impairments in a Rat Model of Alzheimer's disease.Journal of molecular neuroscience : MN · 2026Article
- Selective Detection of Fe(III) and Al(III) Using an Azo-Functionalized Rhodamine B Chemosensor: Expansion to F- Ion Detection by Al(III)-Probe Complex.Chemistry, an Asian journal · 2026Article
- Therapeutic role of deferasirox loaded niosomes against aluminium-maltolate induced Alzheimer disease: A study in Swiss albino mice.The Indian journal of medical research · 2026Article
- Neuroprotective effects of luteolin against aluminum-induced brain injury via chelation and antioxidant pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Design and Development of Solvent-Sensitive Zn(II)/Al(III) Responsive Chemosensor: Extension to the Real-World Application.ChemPlusChem · 2026Article
- Evaluation of Suitability, Efficacy, and Safety of Zinc Hydroxide Adjuvant System Adsorbed on Tetanus Toxoid Vaccine.Molecular biotechnology · 2026Article
- Cognitive Effects of Aluminum Exposure in Cement Factory Workers: A Mini-Mental State Examination (MMSE) Assessment.La Medicina del lavoro · 2026Article
- Neuroprotective Effects of Berberine Chloride Against the Aluminium Chloride-Induced Alzheimer's Disease in Zebra Fish Larvae.Molecular biotechnology · 2026Article
- Pharmacological Characterization ofRecent advances in inflammation & allergy drug discovery · 2026Article
- Article
- A case report of a 79-year-old female with aluminum toxicity presenting with altered mental status in Eldoret, Kenya.Toxicology reports · 2025Article
- Pharmacological Evaluation and In-Silico Study of Sabinene as a Potential Anti-Alzheimer's Drug in AlClNeurochemical research · 2025Article
- Development of a Pyrone-Fused Tricyclic Scaffold-based Ratiometric Fluorescent Probe for AlJournal of fluorescence · 2025Article
- Investigating Trace and Macro-element Composition of Herbal and Nutraceutical Dietary Supplements Marketed in Oman: Insights into Safety and Labeling.Biological trace element research · 2025Article
- New Perspectives on Canned Fish Quality and Safety on the Road to Sustainability.Foods (Basel, Switzerland) · 2025Review
- Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aluminum (Al) is widely found in the nature. Although the relation between Al and neurodegenerative diseases is still controversial, Al is related with many brain diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Al exposure occurs mainly through environment, occupational, and dietary factors for humans. Al exposure with diet can be through foods, food additives, water, and contamination of Al equipment/utensils. The aim of this review is to summarize various hypotheses, which link Al and neurodegeneration, and to determine the roles of Al exposure through different sources including diet, environment, and occupation. Future studies should be done in vulnerable subgroups of population including children, patients receiving antacid or Al-containing pharmeteucials on a daily basis, patients with reduced renal function, and patients on parenteral nutrition regimens that are likely to be affected by possible adverse health effects of Al. In addition, gender, age, and Al interactions need to be determined. One of the most important challanges in future epidemiological studies is to determine which variables should be controlled. In addition, experimental studies should be more focused and translational. In this context, exposure dose, dose-response effects, and time lapse between exposures and cognitive assessments are very important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.