Evidence map›Paper›PMID 30057606›Full record

ReviewJournal of oncology2018

Research Priorities and Resource Allocation in the Investigation of New Drugs for Cancer in Least Developed Countries.

Ricardo Eccard da Silva, Angélica Amorim Amato, Débora Dornelas Belchior Costa Andrade, Alessandra Vanessa Leite E Silva, Marta Rodrigues de Carvalho, Maria Rita Carvalho Garbi Novaes

Abstract readReview
In one paragraph

Review in Journal of oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Phase 1 Clinical Trials: Challenges and Opportunities in Latin America.Journal of immunotherapy and precision oncology · 2024
    Article
  2. Principles of research ethics: A research primer for low- and middle-income countries.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ricardo Eccard da SilvaOffice of Clinical Trials, Brazilian Health Regulatory Agency (ANVISA), Setor de Indústria Trecho 5, Área Especial 57, 71205-050, Brasília, Brazil.ORCID 0000-0003-2322-7163
Angélica Amorim AmatoFaculty of Health Sciences, University of Brasilia (UnB), Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Brazil.ORCID 0000-0002-8454-5504
Débora Dornelas Belchior Costa AndradeSecretary of Health, Government of the Federal District, Quadra 45, Vila São José (Brazlândia), 72745000 Brasília, Brazil.ORCID 0000-0003-3434-2669
Alessandra Vanessa Leite E SilvaHospital de Base, Secretary of Health, Government of the Federal District, SMHS, Quadra 101, Área Especial, s/n, Asa Sul, 70330-150, Brasília, Brazil.ORCID 0000-0002-2548-481X
Marta Rodrigues de CarvalhoSchool of Medicine, Health Science Education and Research Foundation (FEPECS), SMHN Quadra 03, Conjunto A, Bloco 1, Edifício FEPECS, 70.710-907 Brasília, Brazil.ORCID 0000-0002-8616-6735
Maria Rita Carvalho Garbi NovaesFaculty of Health Sciences, University of Brasilia (UnB), Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer incidence has increased significantly in low- and middle-income countries. The priorities of international health research are not always aligned with the global burden of cancer. This study aims to analyze global tendencies in clinical trials in oncology and discuss research priorities and resource allocation in the investigation of new drugs for cancers that significantly affect the least developed countries. This was a retrospective and analytical study that included data collected from the World Health Organization's International Clinical Trials Registry Platform (ICTRP) in 2014. According to our results, there was a tendency for clinical trials involving breast and lung cancer to be conducted in countries with a lower level of economic development. On the other hand, cervical, stomach, and liver cancer, despite the significant burden that these place on middle- and low-income countries, were studied little among the countries selected. In conclusion, the organizations that most fund research to develop new drugs for cancer treatment continue to show little interest in prioritizing resources to fund research for certain types of cancer such as those of the cervix, stomach, and liver, which have a significant impact in low- and middle-income countries.

Identifiers

PMID30057606
PMCPMC6051037

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.