ArticleInternational dairy journal2018
An improved method for the purification of milk oligosaccharides by graphitised carbon-solid phase extraction.
Article in International dairy journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Comparative Analysis of Oligosaccharide and Phenolic Profiles in White and Red Grape Pomace from California.Molecules (Basel, Switzerland) · 2026Article
- Dual human milk oligosaccharide-fibre utilisation is a selection cue for the weaning gut microbiome.Nature communications · 2026Observational
- A Comprehensive Review of Milk Components: Recent Developments on Extraction and Analysis Methods.Molecules (Basel, Switzerland) · 2025Review
- A Comparative Analysis of Milk Oligosaccharides via LC-MS: Globally Distributed Cattle Breeds and Native Northern Finncattle.Biology · 2024Article
- Drugs in Human Milk Part 1: Practical and Analytical Considerations in Measuring Drugs and Metabolites in Human Milk.Clinical pharmacokinetics · 2024Review
- Human milk oligosaccharides in milk of mothers with term and preterm delivery at different lactation stage.Carbohydrate polymers · 2023Article
- Comparison of Solid-Phase Extraction Sorbents for Monitoring the In Vivo Intestinal Survival and Digestion of Kappa-Casein-Derived Caseinomacropeptide.Foods (Basel, Switzerland) · 2023Article
- Improved methods for mare milk analysis: Extraction and quantification of mare milk carbohydrates and assessment of FTIR-based macronutrient quantification.Frontiers in nutrition · 2023Article
- Dietary Fiber to Starch Ratio Affects Bovine Milk Oligosaccharide Profiles.Current developments in nutrition · 2022Article
- Food glycomics: Dealing with unexpected degradation of oligosaccharides during sample preparation and analysis.Journal of food and drug analysis · 2022Article
- Quality Markers ofFrontiers in nutrition · 2022Article
- Variations in bovine milk oligosaccharides after calving using p-aminobenzoic ethyl ester closed-ring labeling and negative ion electrospray LC/MS/MS.Journal of food and drug analysis · 2021Article
- Bioactives in bovine milk: chemistry, technology, and applications.Nutrition reviews · 2021Review
- Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.Journal of agricultural and food chemistry · 2021Article
- Bovine Colostrum and Its Potential for Human Health and Nutrition.Frontiers in nutrition · 2021Review
- Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways.Nature communications · 2020Article
- Variations in porcine colostrum oligosaccharide composition between breeds and in association with sow maternal performance.Journal of animal science and biotechnology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Milk oligosaccharides (OS) are bioactive molecules that impart a variety of health benefits to the consumer. Techniques commonly used to analyse and quantify OS require optimised extraction methods to separate the OS from more abundant milk components. Solid phase extraction (SPE) is frequently used to isolate milk OS from lactose; however, the literature contains no formal studies on its efficacy in this application. In this study, established SPE conditions were modified to improve the technique's effectiveness in purifying OS from lactose. Low concentrations of acetonitrile (ACN) and trifluoroacetic acid (TFA) were tested for solid phase washing. Lactose removal and retention of many OS were significantly improved when using 4% ACN/0.1% TFA compared with the more common water washing technique. Different behaviours between acidic and neutral OS were evident. The new SPE technique improves extraction efficiency for bovine milk OS in applications that do not require prior lactose hydrolysis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.