Evidence map›Paper›PMID 30057408›Full record

ArticleBritish journal of cancer2018

Treatment and survival of rectal cancer patients over the age of 80 years: a EURECCA international comparison.

Yvette H M Claassen, Nina C A Vermeer, Lene H Iversen, Elizabeth van Eycken, Marianne G Guren, Pawel Mroczkowski, Anna Martling, Antonio Codina Cazador, Robert Johansson, Tamara Vandendael and 9 more

Abstract readComparative Study
In one paragraph

Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Review
  3. Results of radical treatment of locally advanced rectal cancer in geriatric and non-geriatric patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yvette H M ClaassenDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Nina C A VermeerDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Lene H IversenDepartment of Surgery, Aarhus University Hospital, Aarhus, Denmark.
Elizabeth van EyckenBelgian Cancer Registry, Brussels, Belgium.
Marianne G GurenDepartment of Oncology and K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway.
Pawel MroczkowskiInstitute for Quality Assurance in Operative Medicine Ltd at Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Anna MartlingDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Antonio Codina CazadorDepartment of Surgery, Generalitat de Catalunya, Barcelona, Spain.
Robert JohanssonDepartment of Radiation Science, Oncology, Umeå University, Umeå, Sweden.
Tamara VandendaelBelgian Cancer Registry, Brussels, Belgium.
Arne WibeInstitute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology-NTNU, Trondheim, Norway.
Bjorn MollerCancer Registry of Norway, Oslo, Norway.
Hans LippertInstitute for Quality Assurance in Operative Medicine Ltd at Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Harm J T RuttenDepartment of Surgery, Catharina Hospital, Eindhoven, The Netherlands.
Johanneke E A PortieljeDepartment of Gerontology & Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Gerrit J LiefersDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Fabian A HolmanDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Cornelis J H van de VeldeDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Esther BastiaannetDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands. E.Bastiaannet@lumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe optimal treatment strategy for older rectal cancer patients remains unclear. The current study aimed to compare treatment and survival of rectal cancer patients aged 80+.

methodsPatients of ≥80 years diagnosed with rectal cancer between 2001 and 2010 were included. Population-based cohorts from Belgium (BE), Denmark (DK), the Netherlands (NL), Norway (NO) and Sweden (SE) were compared side by side for neighbouring countries on treatment strategy and 5-year relative survival (RS), adjusted for sex and age. Analyses were performed separately for stage I-III patients and stage IV patients.

resultsOverall, 19 634 rectal cancer patients were included. For stage I-III patients, 5-year RS varied from 61.7% in BE to 72.3% in SE. Proportion of preoperative radiotherapy ranged between 7.9% in NO and 28.9% in SE. For stage IV patients, 5-year RS differed from 2.8% in NL to 5.6% in BE. Rate of patients undergoing surgery varied from 22.2% in DK to 40.8% in NO.

conclusionsSubstantial variation was observed in the 5-year relative survival between European countries for rectal cancer patients aged 80+, next to a wide variation in treatment, especially in the use of preoperative radiotherapy in stage I-III patients and in the rate of patients undergoing surgery in stage IV patients.

Indexed as

Combined Modality TherapyDigestive System Surgical ProceduresEuropeFemaleHumansMaleNeoplasm StagingRadiotherapy, AdjuvantRectal NeoplasmsRegistriesSurvival AnalysisTreatment Outcome

Identifiers

PMID30057408
PMCPMC6134121

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.