Evidence map›Paper›PMID 30057402›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2018

Receptor-Interacting Protein 3/Caspase-8 May Regulate Inflammatory Response and Promote Tissue Regeneration in the Periodontal Microenvironment.

Bingbing Yan, Kewen Wei, Lipeng Hou, Taiqiang Dai, Yongchun Gu, Xinyu Qiu, Jiangwei Chen, Yuan Feng, Haode Cheng, Zhuo Yu and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Journal of oral microbiology · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Bingbing YanState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Kewen WeiDepartment of Burns and Plastic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Lipeng HouDepartment of Stomatology, Ninth Hospital, Xi'an, Shaanxi, China (mainland).
Taiqiang DaiDepartment of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Yongchun GuDepartment of Dentistry, First People's Hospital of Wujiang Dist, Nantong University, Suzhou, Jiangsu, China (mainland).
Xinyu QiuResearch and Development Center of Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Jiangwei ChenDepartment of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Yuan FengState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Haode ChengState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Zhuo YuState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Yizhe ZhangDepartment of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Hongmei ZhangDepartment of Burns and Plastic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Dehua LiState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).
Air Force Medical University · CNNational Clinical Research · USGénétique et biologie du développementInstitute of Cardiology · PLNational Medical Research Center of Dentistry and Maxillofacial Surgery · RUPlastic Surgery Hospital · CNStomatology Hospital · CNWujiang District People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Periodontal ligament stem cells (PDLSCs) possess characteristics of multi-potential differentiation and immuno-modulation, and PDLSCs-mediated periodontal tissue regeneration is regarded as a hopeful method for periodontitis treatment. Recent studies demonstrated that RIP3 and caspase8 regulate bacteria-induced innate immune response and programmed necrosis, which is also called necroptosis. This study aimed to determine the role of the RIP3/Caspase8 signal pathway on necroptosis of PDLSCs under the inflammatory microenvironment, both [i]in vitro[/i] and [i]in vivo[/i]. MATERIAL AND METHODS PDLSCs were cultured, and transmission electron microscopy and flow cytometry were used to detect necroptosis. PCR, ALP, and Alizarin Red S staining were used to assess the effect of necroptosis on osteogenesis differentiation of PDLSCs [i]in vitro[/i], while HE and Masson staining were taken after the nude mouse subcutaneous transplant experiment. RESULTS Our research indicates that RIP3/caspase8 can regulate the immune response of PDLSCs, and blockade of RIP3/caspase8 can protect the biological characteristics of the PDLSCs, effectively promoting periodontal tissue regeneration in the inflammatory microenvironment. CONCLUSIONS Inhibiting RIP3/caspase8 can effectively promote periodontal tissue regeneration in the inflammatory microenvironment.

Indexed as

AnimalsCaspase 8Cell DifferentiationChinaFemaleHumansMaleMesenchymal Stem CellsMiceNecrosisOsteogenesisPeriodontal LigamentPeriodontitisPrimary Cell CultureReceptor-Interacting Protein Serine-Threonine KinasesRegenerationCASP8 protein, humanCaspase 8Receptor-Interacting Protein Serine-Threonine KinasesRIPK3 protein, humanNecrosisPeriodontal LigamentperiodontitisReceptor-Interacting Protein Serine-Threonine Kinases

Identifiers

PMID30057402
PMCPMC6080583
OpenAlexW2887532018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.