Evidence map›Paper›PMID 30057174›Full record

ArticleCell host & microbe2018

A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection.

Amanda Jacobson, Lilian Lam, Manohary Rajendram, Fiona Tamburini, Jared Honeycutt, Trung Pham, Will Van Treuren, Kali Pruss, Stephen Russell Stabler, Kyler Lugo and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers.

0numbers the graph read from it
0cells of the map it votes in
299citing papers in PubMed
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

299 citing papers in PubMed, 517 citations in OpenAlex.

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239 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Amanda JacobsonDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Lilian LamDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Manohary RajendramDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Fiona TamburiniDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Jared HoneycuttDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Trung PhamDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Will Van TreurenDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Kali PrussDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Stephen Russell StablerDepartment of CHEM-H, Stanford University, Stanford, CA 94305, USA.
Kyler LugoDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Donna M BouleyDepartment of Comparative Medicine, Stanford University, Stanford, CA 94305, USA.
Jose G Vilches-MoureDepartment of Comparative Medicine, Stanford University, Stanford, CA 94305, USA.
Mark SmithDepartment of CHEM-H, Stanford University, Stanford, CA 94305, USA.
Justin L SonnenburgDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
Ami S BhattDepartment of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Stanford University, Stanford, CA 94305 USA.
Kerwyn Casey HuangDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
Denise MonackDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address: dmonack@stanford.edu.
Stanford University · USChan Zuckerberg Initiative (United States) · US

Funding

Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
TRAINING & OUTREACH COREP50GM107615 · NIGMS · STANFORD UNIVERSITY · PI FERRELL, JAMES E. · 2013 to 2017
$10.9M
Impact of Diet on Intestinal Microbiota-Host DynamicsR01DK085025 · NIDDK · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 2010 to 2026
$6.4M
Mechanisms of persistent Salmonella infectionR01AI116059 · NIAID · STANFORD UNIVERSITY · PI MONACK, DENISE M · 2015 to 2025
$4.6M
Innate Immune Recognition of Intracellular SalmonellaR01AI089722 · NIAID · STANFORD UNIVERSITY · PI MONACK, DENISE M · 2011 to 2014
$1.6M
Phenotypic profiling of bacterial stress response networks: A transformative framework for characterizing and predicting antibiotic targets and interactionsF32AI133917 · NIAID · STANFORD UNIVERSITY · PI RAJENDRAM, MANOHARY · 2018 to 2020
$151k
NIAID NIH HHS F32 AI133917NIAID NIH HHS R01 AI089722NIAID NIH HHS R01 AI116059NIDDK NIH HHS R01 DK085025NIGMS NIH HHS P50 GM107615NIGMS NIH HHS T32 GM007276
6 · The paper itself

Abstract

The intestinal microbiota provides colonization resistance against pathogens, limiting pathogen expansion and transmission. These microbiota-mediated mechanisms were previously identified by observing loss of colonization resistance after antibiotic treatment or dietary changes, which severely disrupt microbiota communities. We identify a microbiota-mediated mechanism of colonization resistance against Salmonella enterica serovar Typhimurium (S. Typhimurium) by comparing high-complexity commensal communities with different levels of colonization resistance. Using inbred mouse strains with different infection dynamics and S. Typhimurium intestinal burdens, we demonstrate that Bacteroides species mediate colonization resistance against S. Typhimurium by producing the short-chain fatty acid propionate. Propionate directly inhibits pathogen growth in vitro by disrupting intracellular pH homeostasis, and chemically increasing intestinal propionate levels protects mice from S. Typhimurium. In addition, administering susceptible mice Bacteroides, but not a propionate-production mutant, confers resistance to S. Typhimurium. This work provides mechanistic understanding into the role of individualized microbial communities in host-to-host variability of pathogen transmission.

Indexed as

AnimalsBacterial SheddingBacteroidesCation Transport ProteinsFatty Acids, VolatileFecal Microbiota TransplantationFecesFemaleGastrointestinal MicrobiomeHost-Pathogen InteractionsIntestinal DiseasesMaleMice, Inbred C57BLNatural Resistance-associated Macrophage Protein 1PropionatesSalmonella InfectionsCation Transport ProteinsFatty Acids, VolatileNatural Resistance-associated Macrophage Protein 1PropionatesBacteroidescolonization resistanceintestineintracellular pHmetabolismmicrobiotapathogen sheddingpropionateSalmonellashort-chain fatty acids

Identifiers

PMID30057174
PMCPMC6223613
OpenAlexW2884218973

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.