Evidence map›Paper›PMID 30057134›Full record

ArticleUltrasound in medicine & biology2018

Fast, Low-Frequency Plane-Wave Imaging for Ultrasound Contrast Imaging.

Jiro Kusunose, Charles F Caskey

Open access · greenAbstract read
In one paragraph

Article in Ultrasound in medicine & biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Application of [Contrast media & molecular imaging · 2022
    Article
  5. Dual-Use Transducer for Ultrasound Imaging and Pulsed Focused Ultrasound Therapy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  6. High-Frequency Multipulse, Plane-Wave Acoustic Contrast Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jiro KusunoseVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Charles F CaskeyVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Radiology and Radiologic Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA. Electronic address: charles.f.caskey@vanderbilt.edu.
Vanderbilt University Medical Center · US

Funding

Multidisciplinary Training in Basic and Translational Imaging of CancerR25CA092043 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2001 to 2015
$6.6M
Training Grant In Radiation BiologyT32CA093240 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREEMAN, MICHAEL L. · 2002 to 2016
$2.3M
NCI NIH HHS R25 CA092043NCI NIH HHS T32 CA093240
6 · The paper itself

Abstract

Plane-wave ultrasound contrast imaging offers a faster, less destructive means for imaging microbubbles compared with traditional ultrasound imaging. Even though many of the most acoustically responsive microbubbles have resonant frequencies in the lower-megahertz range, higher frequencies (>3 MHz) have typically been employed to achieve high spatial resolution. In this work we implement and optimize low-frequency (1.5-4 MHz) plane-wave pulse inversion imaging on a commercial, phased-array imaging transducer in vitro and illustrate its use in vivo by imaging a mouse xenograft model. We found that the 1.8-MHz contrast signal was about four times that acquired at 3.1 MHz on matched probes and nine times greater than echoes received on a higher-frequency probe. Low-frequency imaging was also much more resilient to motion. In vivo, we could identify sub-millimeter vasculature inside a xenograft tumor model and easily assess microbubble half-life. Our results indicate that low-frequency imaging can provide better signal-to-noise because it generates stronger non-linear responses. Combined with high-speed plane-wave imaging, this method could open the door to super-resolution imaging at depth, while high power pulses could be used for image-guided therapeutics.

Indexed as

Contrast MediaAdenocarcinomaAnimalsDisease Models, AnimalFemaleHumansImage EnhancementImage Processing, Computer-AssistedMiceMice, NudeMicrobubblesPancreatic NeoplasmsPhantoms, ImagingUltrasonographyContrast MediaContrast imagingLow frequencyMicrobubblePulse inversionUltrasound

Identifiers

PMID30057134
PMCPMC6170006
OpenAlexW2883970191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.