Evidence map›Paper›PMID 30056824›Full record

ArticleThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2018

JC Virus Granule Cell Neuronopathy as AIDS-Presenting Illness.

Simon Grandjean Lapierre, Xin Dang, Danielle Gilbert, Sylvie Lauzier, Igor J Koralnik, Louiselle LeBlanc

Abstract readCase Reports
In one paragraph

Article in The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Simon Grandjean Lapierre1Infectious Diseases and Microbiology Department,Centre Hospitalier de l'Université de Montréal,Montréal,Québec,Canada.
Xin Dang3Department of Neurological Sciences,Rush University Medical Center,Chicago,Illinios.
Danielle Gilbert5Radiology Department,Hôpital du Sacré Coeur de Montréal,Montréal,QuebecCanada.
Sylvie Lauzier4Neurology Department,Hôpital du Sacré Coeur de Montréal,Montréal,QuebecCanada.
Igor J Koralnik3Department of Neurological Sciences,Rush University Medical Center,Chicago,Illinios.
Louiselle LeBlanc2Infectious Diseases, Immunology and Microbiology Department,Université de Montréal,Montréal,Québec,Canada.

Funding

Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
Pathogenesis of a JC Virus Variant in Pyramidal NeuronsR01NS074995 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2012 to 2016
$1.8M
AIDS-assoc Progressive Multifocal LeukoencephalopathyR21NS046243 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KORALNIK, IGOR J · 2003 to 2004
$350k
NINDS NIH HHS R01 NS047029NINDS NIH HHS R01 NS074995NINDS NIH HHS R21 NS046243
6 · The paper itself

Abstract

JC virus is the etiological agent of progressive multifocal leukoencephalopathy, a white matter demyelinating disease that mostly affects immunocompromised patients. JC virus can also infect neurons and meningeal cells and cause encephalitis, meningitis and granule cell neuronopathy. We report a patient with JC virus granule cell neuronopathy, without concomitant progressive multifocal leukoencephalopathy, presenting as inaugural acquired immune deficiency syndrome-related illness. This patient's human immunodeficiency virus infection remained undiagnosed for several months after neurological symptoms onset. We review JC virus pathophysiology, clinical manifestations, treatment and prognosis, and emphasize the importance of considering human immunodeficiency virus infection and related opportunistic infections in the differential diagnosis of new-onset isolated cerebellar disease.

Indexed as

Cerebellar DiseasesFemaleHumansJC VirusMagnetic Resonance ImagingMiddle AgedPolyomavirus InfectionsDemyelinationGranule cell neuronopathyHIVJC virusNeuroimaging

Identifiers

PMID30056824
PMCPMC8656145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.