Evidence map›Paper›PMID 30056777›Full record

ReviewExpert review of respiratory medicine2018

The effect of obesity on lung function.

Anne E Dixon, Ubong Peters

4 registry-linked trialsAbstract readReview
In one paragraph

Review in Expert review of respiratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 451 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
451citing papers in PubMed, 6 pooled it
51.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04780828 completednot on this mapstarted 2020, after this paper: background citation

Investigation of the Effects of Different Obesity Levels on the Respiratory System: In Our Study, Besides the Effect of Obesity on the Respiratory System, Many Different Parameters Related to Health Will be Compared.

TypeobservationalSponsorIstanbul Medipol University HospitalRan2020 to 2021Enrolled100ConditionsObesity, Adolescent, Obesity, Morbid, Obesity, Abdominal, Obesity, Visceral
NCT05323500 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Senobi Breathing Exercises on Body Fat, Lung Functions and Depression in Obese Women

TypeinterventionalSponsorRiphah International UniversityRan2022 to 2022Enrolled30ConditionsObesityArmsSenobi breathing exercises
NCT05950256 nacompletednot on this mapstarted 2023, after this paper: background citation

Physiological Impact of Surgical Mask and N95 Mask on Obese Operating Room Staff:A Randomized-Controlled Cross-Over Trial

TypeinterventionalSponsorQilu Hospital of Shandong UniversityRan2023 to 2024Enrolled20ConditionsObesityArmsN95 mask and surgical mask
NCT06451601 nacompletednot on this mapstarted 2024, after this paper: background citation

The Metabolic and Respiratory Effects of Intermittent Hypoxia-hyperoxia Therapy in Obese Patients Within the Complex Management of Medical Rehabilitation

TypeinterventionalSponsorBalnear and Rehabilitation Sanatorium TechirghiolRan2024 to 2024Enrolled70ConditionsObesityArmsIntermittent hypoxia-hyperoxia therapy
3 · Its place in the literature

Who cites it

451 citing papers in PubMed, 6 syntheses or guidelines pooled it, 852 citations in OpenAlex.

  1. Laparoscopic versus open repair for umbilical hernia: outcomes and complications.Hernia : the journal of hernias and abdominal wall surgery · 2026
    Pooled it
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  6. Thoracostomy tube withdrawal during latter phases of expiration or inspiration: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Pooled it
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  8. Observational
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  10. Inflammasomes in respiratory diseases: from disease pathogenesis to drug development and use of multi-omics.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
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  16. BMI threshold associates with increased 30-day complications after total thyroidectomy surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
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391 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anne E Dixona Division of Pulmonary and Critical Care Medicine , University of Vermont Larner College of Medicine , Burlington , Vermont , USA.
Ubong Petersa Division of Pulmonary and Critical Care Medicine , University of Vermont Larner College of Medicine , Burlington , Vermont , USA.
University of Vermont · US

Funding

Non-Allergic Late-Onset Asthma of Obesity: Pathophysiology and TherapyR01HL130847 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BATES, JASON HT, DIXON, ANNE E · 2016 to 2019
$2.3M
NHLBI NIH HHS R01 HL130847
6 · The paper itself

Abstract

introductionThere is a major epidemic of obesity, and many obese patients suffer with respiratory symptoms and disease. The overall impact of obesity on lung function is multifactorial, related to mechanical and inflammatory aspects of obesity. Areas covered: Obesity causes substantial changes to the mechanics of the lungs and chest wall, and these mechanical changes cause asthma and asthma-like symptoms such as dyspnea, wheeze, and airway hyperresponsiveness. Excess adiposity is also associated with increased production of inflammatory cytokines and immune cells that may also lead to disease. This article reviews the literature addressing the relationship between obesity and lung function, and studies addressing how the mechanical and inflammatory effects of obesity might lead to changes in lung mechanics and pulmonary function in obese adults and children. Expert commentary: Obesity has significant effects on respiratory function, which contribute significantly to the burden of respiratory disease. These mechanical effects are not readily quantified with conventional pulmonary function testing and measurement of body mass index. Changes in mediators produced by adipose tissue likely also contribute to altered lung function, though as of yet this is poorly understood.

Indexed as

AdultAsthmaBody Mass IndexChildDyspneaHumansLungObesityRespirationRespiratory Function TestsRespiratory Hypersensitivityadipose tissueAirway hyperreactivitypulmonary function

Identifiers

PMID30056777
PMCPMC6311385
OpenAlexW2883921268

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.