Evidence map›Paper›PMID 30056772›Full record

ArticleJournal of feline medicine and surgery2019

Length of efficacy and effect of implant location in adult tom cats treated with a 9.4 mg deslorelin subcutaneous implant.

Stefano Romagnoli, Anna Baldan, Silvia Ferro, Camilla Righetti, Ludovico Scenna, Gianfranco Gabai, Tamara Badon, Christelle Fontaine, Antonio Mollo, Calogero Stelletta and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Infertility In Toms: Clinical approach, experiences and challenges.Journal of feline medicine and surgery · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Stefano Romagnoli1 Department of Animal Medicine, Production and Health, University of Padova, Padova, Italy.
Anna Baldan2 Private Practitioner.ORCID 0000-0002-4428-4864
Silvia Ferro3 Department of Comparative Biomedicine and Food Science, University of Padova, Padova, Italy.
Camilla Righetti2 Private Practitioner.
Ludovico Scenna2 Private Practitioner.
Gianfranco Gabai3 Department of Comparative Biomedicine and Food Science, University of Padova, Padova, Italy.
Tamara Badon1 Department of Animal Medicine, Production and Health, University of Padova, Padova, Italy.
Christelle Fontaine4 Virbac, Carros, France.
Antonio Mollo1 Department of Animal Medicine, Production and Health, University of Padova, Padova, Italy.
Calogero Stelletta1 Department of Animal Medicine, Production and Health, University of Padova, Padova, Italy.
Chiara Milani1 Department of Animal Medicine, Production and Health, University of Padova, Padova, Italy.
University of Padua · ITVirbac (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe objective of this study was to assess duration of efficacy, side effects and return to fertility following use of the 9.4 mg deslorelin implant (Suprelorin 12; Virbac) in cats, and test whether efficacy and duration of action are influenced by implantation site (interscapular vs periumbilical).

methodsSixteen healthy adult tom cats were checked with (1) reproductive examination, (2) gonadotropin-releasing hormone stimulation test and (3) semen collection until achievement of sterility, then with (1) and (2) only at 2, 4, 6 and 12 months, and every 6 months thereafter until treatment effect disappeared.

resultsSerum testosterone reached basal levels by 7 days post-treatment. Semen quality improved initially then started to worsen by 1 month post-treatment and after 70 days post-treatment all cats were sterile. Early in the third month post-treatment there was a significant decrease in testicular volume and penile spikes. Testicular histology was normal upon neutering performed after resumption of fertility. No injection site lesions or treatment-related side effects were observed. There was no difference between periumbilical and interscapular placement for all criteria, but there was a trend for the decrease in testicular volume to last longer and for the regression of penile spikes to start sooner after interscapular administration. One of 16 cats did not respond to treatment. Six cats were lost at variable times during the study while fully responding to treatment. In the cats that completed the study, normal fertility was regained after 805 days, on average, but with a variable duration of effect from 750-850 days. CONCLUSIONS AND RELEVANCE: Treatment with a 9.4 mg deslorelin implant in male cats was effective for a period of 750-850 days, which is 1.5-2 times longer than the effect of the 4.7 mg deslorelin implant. Fertility (based on serum testosterone production and the presence of penile spikes) was regained at the end of the study. Placing implants in the intrascapular vs periumbilical location did not affect duration of suppression of testosterone production. The interscapular location may be characterised by a better efficacy, although further studies are needed to clarify this issue.

Indexed as

Drug ImplantsAnimalsCatsFertilityMaleScapulaSemen AnalysisTestisTriptorelin PamoateUmbilicusdeslorelinDrug ImplantsTriptorelin Pamoatedeslorelinfertilityreproduction controlreversible sterilityTom cat

Identifiers

PMID30056772
PMCPMC6537142
OpenAlexW2885461797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.