Evidence map›Paper›PMID 30056570›Full record

ArticleJournal of neurology2018

Cerebellum and cognition in progressive MS patients: functional changes beyond atrophy?

Sirio Cocozza, Giuseppe Pontillo, Camilla Russo, Cinzia Valeria Russo, Teresa Costabile, Alessio Pepe, Enrico Tedeschi, Roberta Lanzillo, Vincenzo Brescia Morra, Arturo Brunetti and 2 more

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In one paragraph

Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sirio CocozzaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Giuseppe PontilloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Camilla RussoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Cinzia Valeria RussoDepartment of Neurosciences, Reproductive and Odonto-stomatological Sciences, University of Naples Federico II, Naples, Italy.
Teresa CostabileDepartment of Neurosciences, Reproductive and Odonto-stomatological Sciences, University of Naples Federico II, Naples, Italy.
Alessio PepeDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Enrico TedeschiDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Roberta LanzilloDepartment of Neurosciences, Reproductive and Odonto-stomatological Sciences, University of Naples Federico II, Naples, Italy.
Vincenzo Brescia MorraDepartment of Neurosciences, Reproductive and Odonto-stomatological Sciences, University of Naples Federico II, Naples, Italy.
Arturo BrunettiDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Matilde IngleseDepartments of Neurology, Radiology and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1137, New York, NY, 10029-6579, USA. matilde.inglese@mssm.edu.
Maria PetraccaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

National Multiple Sclerosis Society RG 5120A3/1
6 · The paper itself

Abstract

backgroundThe cerebellum is a predilection site of pathology in progressive multiple sclerosis (PMS) patients, contributing to cognitive deficits. Aim of this study was to investigate lobular cerebellar functional connectivity (FC) in PMS patients in relation to cognition.

methodsIn this cross-sectional study, resting state fMRI analysis was carried out on 29 PMS patients (11 males, mean age 51.2 ± 11.9 years) and 22 age- and sex-matched healthy controls (HC) (11 males, mean age 49.6 ± 8.8 years). Data were analyzed with a seed-based approach, with four different seeds placed at the level of cerebellar Lobule VI, Crus I, Crus II and Lobule VIIb, accounting for cerebellar structural damage. Cognitive status was assessed with the BICAMS battery. Correlations between fMRI data and clinical variables were probed with the Spearman correlation coefficient.

resultsWhen testing FC differences between PMS and HC without taking into account cerebellar structural damage, PMS patients showed a reduction of FC between Crus II/Lobule VIIb and the right frontal pole (p = 0.001 and p = 0.002, respectively), with an increased FC between Lobule VIIb and the right precentral gyrus (p < 0.001). After controlling for structural damage, PMS patients still showed a reduced FC between Crus II and right frontal pole (p = 0.005), as well as an increased FC between Lobule VIIb and right precentral gyrus (p = 0.003), with the latter showing an inverse correlation with BVMT scores (r = - 0.393; p = 0.03).

conclusionPMS patients show cerebellar FC rearrangements that are partially independent from cerebellar structural damage, and are likely expression of a maladaptive functional rewiring.

Indexed as

CognitionAdultAgedBrain MappingCerebellumCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple Sclerosis, Chronic ProgressiveNeural PathwaysProspective StudiesRestCerebellumFunctional connectivityProgressive multiple sclerosisResting state fMRI

Identifiers

PMID30056570

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.